A total of 32,207patients with various rheumatic disorders were treated with the non-steroidal antiphlogistic tolmetin in the course of a post-marketing survey performed in Italy with the co-operation of 4,205 general practitioners. The treatment proved effective in about 90% of patients treated. The tolerability of the drug was excellent or good in 91% of cases. Side-effects involving mostly the gastro-intestinal tract occurred in 12.3% of cases, but treatment was discontinued in only 3.6% of patients. The results confirm the remarkable therapeutic activity and the good tolerability of tolmetin sodium.
Get full access to this article
View all access options for this article.
References
1.
BachmannFStroescuOHartl (1975) Double-blind and dose range studies with tolectin in rheumatoid arthritis. Zeitscrift fur Allegemeinmedizin Der Landarzt (Stuttgart)30, 1382.
2.
BernhardG CPoileyJTarpleyE L (1975) A double-blind co-operative trial of tolmetin plus gold in the treatment of rheumatoid arthritis. In: Tolmetin: a New Non-Steroidal Anti-Inflammatory Agent. WardR J, ed. Excerpta Medica, Amsterdam-Princeton, p. 122.
3.
CardoeNSteelC E (1977) A double-blind cross-over comparison of tolmetin sodium and phenylbutazone in the treatment of rheumatoid arthritis. Current Medical Research and Opinion4, 688.
4.
KlempPMeyersO L (1977) Clinical trial of tolmetin and aspirin in the treatment of rheumatoid arthritis. South African Medical Journal52, 167.
5.
MaibachE (1977) Treatment of extra-articular rheumatic diseases and fresh distortions with tolectin. Therapiewoche27, 2318.
6.
ManzGFrankeM (1977) The treatment of ankylosing spondylitis with Tolectin and indomethacin. A randomized double-blind study. Therapiewoche27, 2288.
7.
MullerF OGoslingJ AErdmannG H (1977) A comparison of tolmetin with aspirin in the treatment of osteo-arthritis of the knee. South African Medical Journal51, 794.
8.
RauRLobsingerMGrossD (1977) Treatment of severe osteoarthrosis of the knee and the hip with tolmetin (A double-blind comparison with indomethacin). Praxis66, 147.
9.
RotsteinJ (1975) A comparative study of tolmetin versus placebo in the treatment of rheumatoid arthritis. In: Tolmetin: a New Non-Steroidal Anti-Inflammatory Agent. WardJ R, ed. Excerpta Medica, Amsterdam – Princeton, p. 34.
10.
SchattenkirchnerMSchattenkirchnerUMuller-FassbenderA (1977) Clinical experience with Tolmetin in the long-term treatment of ankylosing spondylitis. Therapiewoche27, 2298.
