Twenty-two patients suffering from asthma or chronic bronchitis were treated in a double-blind crossover study with a slow-release and with a conventional aminophylline preparation. The serum theophylline concentrations were maintained longer with the slow-release preparation, and the morning through levels were 21% higher (p < 0.05 for the difference) than with the plain preparation. The serum levels of theophylline were low with the small daily doses used, and there was no clear correlation between lessening of the obstruction and serum theophylline.
HillsMArmitageP (1979) The two-period crossover clinical trial. British Journal of Clinical Pharmacology8, 7.
3.
JonesR W (1979) Comparative pharmacokinetics of two theophylline derivatives in asthmatic patients. Journal of International Medical Research7, Suppl. 1, 16.
4.
LeastC JJohnsonG FSolomonH M (1976) Gas-chromatographic micro-scale procedure for theophylline, with use of a nitrogen-sensitive detector. Clinical Chemistry22, 765.
5.
OgilvieR I (1978) Clinical pharmacokinetics of theophylline. Clinical Pharmacokinetics3, 267.
6.
TrembathP WBoobisS WRichensA (1979) Theophylline: Biochemical pharmacology and pharmacokinetics. Journal of International Medical Research7, Suppl. 1, 4.
