A double-blind randomized clinical trial was conducted in eighty-seven patients with mild, moderate or severe dental surgery pain to evaluate the analgesic activity of a single oral dose of the following compounds: (i) ibuprofen 400 mg, (ii) ACC-30 (a compound containing ASA 375 mg; codeine phosphate 30 mg; caffeine citrate 30 mg), (iii) placebo.
Ibuprofen was significantly better than ACC-30 and placebo on almost all pain intensity, degree of relief and duration of analgesia parameters. ACC-30 was not significantly different from placebo on any analgesic measurement. No serious side-effects were reported with any of the study medications.
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References
1.
AdamsS SMcCulloughK FNicholsonJ S (1969) The pharmacological properties of ibuprofen, an anti-inflammatory, analgesic and anti-pyretic agent. Archives Internationales de Pharmacodynamic178, 115.
2.
BrooksC DSchmidF RBiundoJBlauSGonzalez-AlcoverRGowansJ D CHurdEPartridgeR E HTarpleyE L (1970) Ibuprofen and aspirin in the treatment of rheumatoid arthritis; a comparative double-blind trial. Rheumatology and Physical Medicine (Supplement) 48.
3.
ClementD B (1975) New agent may help in soft tissue therapy. The Physician in Sportsmedicine3, 45.
4.
CooperS ANeedleS EKrugerG O (1977) Comparative analgesic potency of aspirin and ibuprofen. Journal of Oral Surgery35, 898.
5.
CorsonS LBologneseR J (1978) Ibuprofen therapy for dysmenorrhea. Journal of Reproductive Medicine20, 246.
6.
GiansiracusaJ EDonaldsonM SKoonceM LLeftonT ERuoffG EBrooksC D (1977) Ibuprofen in osteoarthritis. Southern Medical Journal70, 49.
7.
IlesJ D H (1980) Relief of post operative pain by ibuprofen: A report of two studies. The Canadian Journal of Surgery23, 288.
8.
PorroG BCorviGFuccellaL MGoldanigaG CValzelliG (1977) Gastro-intestinal blood loss during administration of indoprofen, aspirin and ibuprofen. Journal of International Medical Research5, 155.
9.
RondeauP LYeungENelsonP (1980) Dental surgery pain. Journal of Canadian Dental Association7, 433.
10.
WilsonW LListonA JMcKimT RMorrisonA B (1979) Trends in narcotic drug consumption in Canada. Canadian Pharmaceutical Journal113, 19.
11.
WinterLBassERecantBCahalyJ F (1978) Analgesic activity of ibuprofen (Motrin) in postoperative oral surgical pain. Oral Surgery45, 159.
