Plasma theophylline concentrations were measured in six volunteers given 675 mg of a sustained-release preparation (Phyllocontin®). Significant reductions in both the mean recorded peak theophylline plasma concentrations and the mean 12-hour theophylline bioavailability were observed after the administration of effervescent activated charcoal (Medicoal®) in single and multiple doses. These results indicate the potential use of activated charcoal in the management of theophylline poisoning.
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