Two hundred and seventy patients suffering from the sequelae of different forms of brain injury have been treated orally with pyritinol 200 mg three times a day for a period of 6 weeks. It has been shown that, compared with placebo therapy, pyritinol produces statistically significant improvement in the clinical and psychoneurological manifestations. It is concluded that pyritinol is a drug of therapeutic benefit in the treatment of the sequelae of cerebral trauma.
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References
1.
ArakiC H (1948) Geka10, 4, 193.
2.
CooperA JMagnusR V (1980) A placebo controlled study of pyritinol (Encephabol) in dementia. Pharmatherapeutica2, 5, 317.
3.
OreG DaneBricoloAAlexandreA (1980) The influence of the administration of pyritinol on the clinical course of traumatic coma. Journal of Neurosurgical Sciences24, 1.
4.
DoberauerWDoberauerB (1975) Drug therapy of cerebral insufficiency in old age. Der Praktische. Arzt.28, 1257.
5.
Fehling-JossC (1974) Influence of dyslexic factors by pyritinol hydrochloride. Clinical Trials Journal11, 4, 123.
6.
GerstenbrandFGrünbergerJSchultesH (1969) Treatment with drugs in the rehabilitation of persons suffering from brain injuries (experience with pyrithioxin). Congress Report 2nd Danube Symposium for Neurology, Vienna.
7.
HamouzW (1977) The use of pyritinol in patients with moderate to severe organic psychosyndrome. Pharmatherapeutica1, 398.
8.
HerrschaftH (1978) Effect of pyritinol on the cerebral blood circulation in man. München Medizin Wochenschrift39, 1263.
9.
HockadayJ MPottsFEpsteinEBonazziASchwabRS (1965) Electroencephalography changes in acute cerebral anoxia. Electroencephalography and Clinical Neurophysiology18, 575.
10.
HoyerSOsterreichKStollK D (1977) Effects of pyritinol HCL on blood flow and oxidation metabolism of the brain in patients with dementia. Arzneimittel-Forschung (Drug Research)27, 671.
O'KellyD J Lane (1975) Pyritinol in the treatment of chronic alcoholics. Journal of International Medical Research3, 5, 323.
13.
LogueGNestadtANeumannY (1974) The effects of pyrithioxine on the behaviour and intellectual functioning of learning disabled children. South African Medical Journal48, 9, 2245.
14.
StoicaEStefanescuEGheorghiuM (1972) The restoration of the reactivity of higher autonomic centres by pyrithioxin administration in cerebral infarct patients. European Neurology7, 348.
15.
WildV KDolceG (1976) Pathophysiological aspects concerning the treatment of the Apallic syndrome. Journal Neurology213, 143.
