Fifty-eight children, 1 to 12 years old, with either acute otitis media or acute maxillary sinusitis were treated with co-trimazine once daily over a period of 10 days. All of the children with otitis and all but two with sinusitis were cured. The drug was excellently tolerated and well accepted.
Get full access to this article
View all access options for this article.
References
1.
BjönnessHGuglerE (1973) Treatment of sinusitis in children. Comparative studies with bactrim and penicillin. Therapeutische Umschau30, 452.
2.
BushbyS R MHitchingsG H (1968) Trimethoprim, a sulphonamide potentiator. British Journal of Pharmaceuticals and Chemotherapeutics33, 72.
3.
CameronG GPomahacA CJohnstonM T (1975) Comparative efficacy of ampicillin and trimethoprim-sulphamethoxazole in otitis media. C M A Journal112, 878.
4.
DarellJ HGarrodL PWaterworthP M (1968) Trimethoprim, clinical and laboratory studies. Journal of Clinical Pathology21, 202.
5.
EkströmBFellnerHForsgrenUMagniLÖrtengrenB (1979) Antibacterial activity of co-trimazine in vitro and in vivo. Infection7, 74.
6.
KühniMBöhniEGambaGBraunsteinerA (1972) Vergleichende klinische und bakteriologische Untersuchungen mit Trimethoprim/Sulfmethoxazol und Ampicillin in der Paediatrie. Paediatrie und Paedologie7, 384.
7.
OrtengrenBFellnerHBerganT (1979) Development of sulphonamide – trimethoprim combinations for urinary tract infections: Part II. Infection7, Suppl 4, 367.
8.
ÖrtengrenBMagniLBerganT (1979) Development of sulphonamide – trimethoprim combinations for urinary tract infections: Part III. Infection7, Suppl 4, 371.
9.
ReevesD SWilkinsonP J (1979) The pharmacokinetics of trimethoprim and trimethoprim/sulphonamide combinations, including penetration into body tissues. Infection7, Suppl 4, 330.
10.
WillnerM MDullI AMacDonaldH (1978) Comparison of trimethoprim – sulphamethoxazole and ampicillin in the treatment of acute bacterial otitis media in children. Current Chemotherapy1, 125.
