Comparison of a Paper Pill with a Conventional Oral Contraceptive Tablet

Abstract

A multicentre clinical trial comparing a novel formulation (the Paper Pill) of a combined oral contraceptive containing 30 μg ethinyloestradiol and 150 μg levonorgestrel with a conventional tablet formulation (Microgynon 30) has been carried out in 336 women over 6 cycles. There were no pill failures in women taking either preparation with one exception in the Microgynon 30 group which was due to poor patient compliance. Cycle control judged by cycle length, duration and amount of withdrawal bleeding and the incidence of intermenstrual bleeding was good in both groups. The number of adverse effects was slightly less in the Paper Pill group and fewer withdrawals for medical reasons were noted than in the Microgynon 30 group. A questionnaire showed that the Paper Pill was accepted well by the majority of women in the trial.

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References

Brat

(1974) Clinical trial with a new low oestrogen combined oral contraceptive. Current Medical Research and Opinion 2, 465.

Bye

P G T

(1976) Analysis of a multicentre trial of a new low-dose oral contraceptive in Great Britain. Acta Obstetricia et Gynecologica Scandinavica Supplement 54, 61.

Bye

P G T

Elstein

(1973) Clinical assessment of a low-oestrogen, low-dose progestogen combined oral contraceptive. British Medical Journal 19th May, 389.

Allen

H Hugh

(1974) Clinical assessment of a low-dose oestrogen, low-dose progestogen combined oral contraceptive. Current Medical Research and Opinion 2, 101.

Morris

S E

(1977) Comparison of the effects on circulating hormone levels of a ‘conventional’ and a ‘paper’ pill oral contraceptive. Proceedings of an International Symposium on Hormonal Contraception Eds. Haspels

A A

Kay

C R

(Excerpta Medica). p 89.

Woutersz

T B

(1974) A new low-oestrogen, low-progestogen combined oral contraceptive. Current Medical Research and Opinion 2, 95.