The present study evaluated the efficacy of 25 mg of quazepam, a new benzodiazepine hypnotic, in a population of chronic insomniacs. The results indicate that a single dose (25 mg) administered for one night was efficacious when measured both objectively by polysomnographic recording and subjectively by questionnaire with no reported side-effects. The change in the objective measures paralleled the direction of change in subjective measures. Sleep efficiency and sleep maintenance were improved without EEG changes in Stages 2, 3-4, and REM. Further study is needed to evaluate the effects of chronic administration of different doses of quazepam in chronic insomniacs.
Get full access to this article
View all access options for this article.
References
1.
FreemanF RAl-MarashiM S HLeeJ C M (1977) The effect of a new benzodiazepine hypnotic on the polygraphically monitored sleep of normal volunteers. Journal of Clinical Pharmacology17, (7), 398.
2.
KalesAMalstromE JScharfM BRubinR T (1969) Psychophysiological and biochemical changes following use and withdrawal of hypnotics. In: Sleep: Physiology and Pathology. KalesA (Ed). J B Lippincott, Philadelphia.
3.
RechtschaffenAKalesA (1968) A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. US Department HEW Public Health Service, NIMH National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA.
