A retrospective epidemiological study was conducted in Greece during 1975 to assess the incidence of agranulocytosis following treatment with dipyrone. Twenty-four cases of agranulocytosis were reported, of which fifteen were possibly associated with medication. If all fifteen cases are attributed to dipyrone, the incidence of agranulocytosis following treatment with this drug lies between one case in every 133,000 and one case in every 466,000 treatments.
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