Amoxycillin for Parenteral Use: A Pharmacological and Clinical Evaluation

Abstract

Pharmacological studies with intramuscular amoxycillin and intramuscular ampicillin were carried out in ten patients. Serum, urine levels, urinary recovery and renal clearance of intramuscular amoxycillin were similar to intramuscular ampicillin and to oral amoxycillin. The time to peak serum concentration was later for amoxycillin. Sputum levels were higher for amoxycillin. Amoxycillin intramuscularly was more painful than ampicillin in eleven out of thirty patients. The clinical response, evaluated in twenty-five patients was good and similar to ampicillin in our experience.