Cardiovascular Effects of Intravenous Indoramin Hydrochloride in Man

Abstract

Haemodynamic effects of intravenous indoramin (5–20 mg) were measured in ten healthy volunteers. Slight falls in arterial and central venous blood pressures were noted but no significant changes in heart rate, right atrial pressure, cardiac output or derived values occurred, except for a fall in peripheral vascular resistance in three cases. An increase in skin blood flow to the feet was observed.

An attempt was made to determine the mechanism of these responses and it was concluded that the drug was an alpha adrenoceptor blocking agent which appeared to act preferentially on those receptors controlling blood flow to the skin of extremities.