Sixty-eight steroid-independent children, whose asthma was poorly controlled by bronchodilators and other anti-asthmatic drugs, were treated for six weeks with 200 to 400 mcg per day of beclomethasone dipropionate aerosol.
Symptoms of wheezing, blockage, and cough, reported by the children in a daily diary, improved in 80% of cases. Use of other anti-asthmatic medications, which the children were free to modify as they wished, decreased.
Objective measurements of pulmonary function, VC, FEV1, and FEV%, evaluated by weekly spirometry, also improved in almost 80% of cases. The dosages used here had no effect on early morning plasma Cortisol levels and none of the children developed signs of oral candidiasis.
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References
1.
AnderssonE (1975) An investigation of the bronchial mucous membrane after long-term treatment with beclomethasone dipropionate. Postgraduate Medical Journal51, (Suppl 4), 32.
2.
AnderssonASmidtC M (1974) An investigation of the bronchial mucous membrane after long-term treatment with beclomethasone dipropionate. Acta Allergologica (Kbh)29, 354.
3.
BakeB (1977) Lung function test for assessment of effects of drugs in asthma. Scandinavian Journal of Respiratory Diseases (Suppl 101), 25.
4.
BrockbankWBrebnerHPengellyC D R (1956) Chronic asthma treated with hydrocortisone aerosol. Lancet2, 807.
5.
BrownHStoreyG (1975) Treatment of allergy of the respiratory tract with beclomethasone dipropionate steroid aerosol. Postgraduate Medical Journal51, (Suppl 4), 59.
6.
BrownH MorrowStoreyGGeorgeW H S (1972) Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. British Medical Journal1, 585.
7.
EberleinW RBongiovanniA MRodriquezC S (1967) Complications of steroid treatment. Pediatrics40, 279.
8.
FreedmanB J (1978) Rate of bronchodilation with rimiterol aerosol. Practitioner220, 476.
9.
FreigangB (1977) New method of beclomethasone aerosol administration in children under 4 years of age. Canadian Medical Association Journal117, 1308.
10.
GaddieJSkinnerCPalmerK N V (1975) Beclomethasone dipropionate aerosol; studies in chronic bronchial asthma. Postgraduate Medical Journal51, (Suppl 4), 50.
11.
GelfandM L (1951) Administration of cortisone by the aerosol method in the treatment of bronchial asthma. New England Journal of Medicine245, 293.
12.
GodfreyS (1975) The long-term evaluation of beclomethasone dipropionate in childhood asthma. Postgraduate Medical Journal51, (Suppl 4), 90.
13.
GwynnC MSmithJMorrison (1974) A 1-year follow-up of children and adolescents receiving regular beclomethasone dipropionate. Clinical Allergy4, 325.
14.
HarrisD M (1975) Some properties of beclomethasone dipropionate and related steroids in man. Postgraduate Medical Journal51, (Suppl 4), 20.
15.
HarrisL (1975a) Clinical Respiratory Physiology, Baltimore, Williams and Wilkins Company.
16.
JonesR S (1973) Beclomethasone in childhood asthma. Archives of Diseases of Childhood48, 663.
17.
KennedyM C S (1973) Treatment of asthma with beclomethasone dipropionate aerosol. Bull. Physiopathol. Respir. (Nancy)9, 816.
18.
KerrebijnK F (1976) Beclomethasone dipropionate in long-term treatment of asthma in children. Journal of Pediatrics89, 821.
19.
KerrebijnK FDeKroonJ P M (1968) Effect on height of corticosteroid therapy in asthmatic children. Archives of Diseases of Childhood43, 556.
20.
KleinRWaldmanDKershnarH (1977) Treatment of chronic childhood asthma with beclomethasone dipropionate aerosol: 1 A double-blind cross-over trial in nonsteroid-dependent patients. Pediatrics60, 7.
21.
KravisL PLecksH I (1966) Inhalation vs oral steroid therapy in childhood asthma. American Journal of Diseases of Childhood111, 343.
22.
LinderW R (1964) Adrenal suppression by aerosol steroid inhalation. Archives of Internal Medicine113, 655.
23.
LoveraJCooperD MCollins-WilliamsC (1976) Clinical and physiological assessment of asthmatic children treated with beclomethasone dipropionate. Journal of Allergy and Clinical Immunology57, 112.
24.
MackayJ B (1975) The impact of beclomethasone dipropionate aerosol on patients with reversible airways obstruction attending a chest clinic. Postgraduate Medical Journal51, (Suppl 4), 37.
25.
MartinL EHarrisonCTannerR J N (1975) Metabolism of beclomethasone dipropionate by animals and man. Postgraduate Medical Journal51, (Suppl 4), 11.
26.
McAllenM KKochanowskiS JShawK M (1974) Steroid aerosols in asthma: an assessment of betamethasone valerate and a 12-month study of patients on maintenance treatment. British Medical Journal1, 171.
27.
McFaddenE RIngramR HJr (1976) Spirometry, lung volumes, and distribution of ventilation in asthma. In: Bronchial Asthma; Mechanisms and Therapeutics. Edited by WeissE BSegalM S, Boston, Little, Brown and Company.
28.
NoveyH SBeallG (1965) Aerosol steroids and induced Cushing's syndrome. Archives of Internal Medicine115, 602.
29.
RonchettiRGentiliG (1976) II beclometasone nella terapia dell'asma infantile. [Beclomethasone in the treatment of childhood asthma.]Minerva Pediatrica28, 478.
30.
SpitzerS AKaufmanHKoplovitzA (1976) Beclomethasone dipropionate and chronic asthma. Chest70, 38.
31.
ToogoodJ HLefcoeN M (1965) Dexamethasone aerosol for the treatment of ‘steroid-dependent’ chronic bronchial asthmatic patients. Journal of Allergy36, 321.
32.
ValentineM DTalamoR C (1976) Commentary: The role of beclomethasone (Vanceril) in the therapy of asthma. Journal of Paediatrics89, 827.
33.
VandenbergRToveyELoveI (1975) Beclomethasone dipropionate; trial of a new inhalation steroid preparation in the treatment of steroid-dependent chronic asthmatics. Medical Journal of Australia1, 189.
34.
VogtFChervinskyPDwekJ (1976) Beclomethasone dipropionate aerosol in the treatment of chronic bronchial asthma. Journal of Allergy and Clinical Immunology58, 316.
35.
WilleyR FMilneL J RCromptonG K (1976) Beclomethasone dipropionate aerosol and oropharyngeal candidiasis. British Journal of Diseases of the Chest70, 32.
36.
ZwiSGoldmanH IVan AsA (1975) The measurement of response to beclomethasone dipropionate treatment for asthma. Postgraduate Medical Journal51, (Suppl 4), 64.
