Abstract
A retrospective evaluation has been made of blood pressure, pulse rate, and number of anginal attacks per day in twenty-one patients diagnosed as Prinzmetal's A ngina and treated with the investigational drug nifedipine. The effect of combining nifedipine with short- and long-acting nitrates or with propranolol was also evaluated.
In consideration of the statisically significant reduction in the number of anginal attacks per day, p<0.001, together with the non-significant mean changes in blood pressure and pulse rate as well as the compatability with the other drugs, it is concluded that nifedipine is a very useful drug, in a dose range of 30–120 mg per day, for the treatment of Prinzmetal's Angina. Recorded side-effects were of minimal severity and in no case caused nifedipine therapy to be discontinued.
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