An open trial of the use of amoxycillin injection in the treatment of pyogenic meningitis in children showed similar results to previous trials here of penicillin-chloramphenicol combinations. It is felt that, in developing countries at least, treatment of pyogenic meningitis in children should be with the latter combination, but where rapid and accurate bacteriology is available amoxycillin may be a valuable non-toxic alternative to chloramphenicol with similar activity to ampicillin.
Get full access to this article
View all access options for this article.
References
1.
ChintuCBathirunathanN (1975) Bacterial meningitis in infancy and childhood in Lusaka. Zambia Medical Journal9, 150.
2.
FeldmanW ELaupusW ELedaalP (1976) Relapse of Haemophilus influenzae type B meningitis after combined antibiotic therapy: report of a case. Paediatrics57, 387.
3.
GaboneseR HZumhireH Nsan (1976) Meningitis in Karouwe District. Dar Es Salaam Medical Joumal7, 34.
4.
HambletonGDaviesP A (1975) Bacterial meningitis. Archives of Diseases of Childhood50, 674.
5.
HeycockJ BNobleT C (1964) Pyogenic meningitis in infancy and childhood. British Medical Journal1, 658.
6.
HunterP ARolinsonG NWittingD A (1973) Comparative activity of amoxycillin and ampicillin in experimental bacterial infection in mice. Antimicrobial Agents and Chemotherapy4, 285.
7.
JonesK HHillS A (1974) Absorption and distribution characteristics of amoxycillin (BRL 2333). Progress in Chemotherapy and Antibacterial Chemotherapy. Proceedings of the 8th International Congress of Chemotherapy.
8.
KatzS L (1975) Ampicillin resistant Haemophilus influenzae. A status report. Paediatrics55, 6.
9.
KendallS R (1972) Ampicillin failure in Haemophilus influenzae meningitis. Clinical Paediatrics2, 264.
10.
KhanA AMaguireM J (1978) Rifampicin in the treatment of acute pyogenic meningitis. Tropical Paediatrics (in press).
11.
MaguireM JKhanA A (1978) The current state of paediatrics in UTH Zambia. Zambia Medical Journal (in press).
12.
MartenA (1976) Chloramphenicol resistance in Haemophilus influenzae. Lancet1, 702.
13.
MathiesA W (1975) Experience with ampicillin in bacterial meningitis. Antimicrobial Agents and Chemotherapy610.
14.
NeuH C (1974) Antimicrobial activity and human pharmacology of amoxycillin. Journal of Infectious Diseases129, 123.
15.
SutherlandRCroydonE A PRolinsonG N (1972) Amoxycillin: A new semisynthetic penicillin. British Medical Journal3, 13.
