Abstract
In two centres a total of 50 patients with anxiety neurosis was studied in a randomised, between patient, double blind comparison of the therapeutic efficacies of two new anxiolytic agents, oxypertine (Integrin) and medazepam (Nobrium). Treatment was continued for four weeks. Assessments were made using the Middlesex Hospital Questionnaire (MHQ), the Hamilton Anxiety Scale and the Graphic Scale. On all three ratings both agents produced a significant improvement in the patients' condition. Significant differences between the two agents were recorded by the MHQ sub tests and total score. Phobic anxiety responded significantly better to medazepam (p < 0·03). Depression responded significantly better to oxypertine (p < 0·02) which was also associated with a greater improvement in three of the remaining four sub tests and a significantly greater reduction in score for overall neuroticism (p < 0·05).
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