A multiclinical cooperative clinical trial at three university clinics in Tokyo is described. The three components of an anti-hypertensive combination have been compared with placebo in double blind fashion alone and in the possible combinations.
The patients were treated with flexible doses during four weeks (max dose 3 caps/day). For statistical evaluation 159 patients were available. In mild to moderate hypertension the combination of the three components caused, in lower doses, a significantly greater blood pressure reduction than the components separately or combinations of two. No important side-effects were encountered.
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