One hundred and fifty-five patients suffering from T. Capitis. T. Corporis. T. Cruris and T. Versicolor participated in studies of topically applied griseofulvin. Various concentrations of the drug were prepared in an ointment form in a new solvent system. Successful results were obtained with the 2% preparation in cases of T. Corporis, T. Cruris and T. Versicolor. Failure of the therapy was observed in cases of T. Capitis. No side-effects occurred in any patient using the 2% preparation. In the opinion of the authors, topically applied griseofulvin in the new solvent system is safe and highly effective in the treatment of superficial dermatomycoses.
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References
1.
ArievichAMZisermanVE (1972) Experience of topical application of griseofulvin for treatment of some mycotic lesions of the skin. Veskuk dermalologii venerologii, 46, 82
2.
BlankHRothFJJ (1959) The treatment of dermatmycoses with orally administered griseofulvin AMA. Archives of Dermatology, 79, 259
3.
BusfieldD (1963). Lancet, 11, 1042
4.
EpsteinWLShahVPRiegelmanS (1972) Griseofulvin levels in stratum corncum. Archives of Dermatology106, 344
5.
EpsteinWLShahVPJonesHERiegelmanS (1975) Topically applied griseofulvin in prevention and treatment of Trichophyton mentagrophites. Archives of Dermatology111
6.
GentlesJC (1958) Experimental ring-worm in guinea pigs: Oral treatment with griseofulvin. Nature182, 476
HoferWHonemannWKochE (1968) Zur behandlung der dermatomykosen mit gricin. Salbe. Deutsche gresundheitswesen23, 370
9.
KrughtAG (1974) The activity of various topical griseofulvin preparation and the appearance of oral griseofulvin in the stratum corneum. British Journal of Dermatology91, 49
10.
LevineHBCobbJMFriedmanRH (1971) Griseofulvin penetration into guinea pig skin and clinical findings in felnic ring-worm. Sabouraudia9, 43
11.
MortonAR (1959) The systemic and local treatment of experimental dermatophytoses with griseofulvin. Journal of Investigative Dermatology32, 525
12.
OxfordAERaistrickHSimonantP (1939) Studies in the biochemistry of micro organism LX. Griseofulvin C18H17O6Cl, a metabolic product of Pénicillium griseofulvin Diercka. Biochemistry Journal33, 240
