In a double-blind investigation, 36 patients suffering from various steroid-responsive dermatoses were treated twice daily for three weeks either with 0·05% betamethasone 17,21-dipropionate cream or with 0·05% clobetasol propionate cream. Results showed both products to be highly effective in terms of onset of action and efficacy and no statistical differences were found (p > 0·1).
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References
1.
AllenbyCF (1975) Effect on adrenal function of topically applied clobctasol propionate (Dermovate). British Medical Journal4, 619
2.
BjörnbergAHellgrenL (1975) Treatment of psoriasis with clobctasol propionate: a double-blind comparison with betamethasone valerate. Current Medical Research and Opinion3, 36
3.
BoxleyJD (1975) Generalized pustular psoriasis on withdrawal of clobctasol propionate ointment. British Medical Journal2, 255
4.
ChambersWBCashWSMarinaccioA (1976) Diprosone (betamethasone dipropionate) cream 0·05%. Review and report of a multicentre study. Journal of International Medical Research4, Suppl (3), 1
FeiwalMKellyWJ (1974) Adrenal unresponsiveness associated with clobctasol propionate. Lancet2, 112
7.
GiardAPonsD (1974) Dermocorticothérapie. Diprosone: étude statistique sur 6,000 cas. Gazette Médicale de France, Suppl 1–91, Sept 1974
8.
HersleKMobackenH (1975) A double-blind evaluation of betamethasone 17,21-dipropionate (Diproderm ointment) in comparison with fluclorolone acetonide (Topilar ointment) in psoriasis. Current Therapeutic Research18 (6), 812
9.
LassusA (1976a) Local treatment of psoriasis with clobetasol propionate and betamethasone 17,21-dipropionate: a double-blind comparison. Current Medical Research and Opinion3, 693
10.
LassusA (1976b) Local treatment of psoriasis of the scalp with clobetasol propionate in alcoholic solution: a comparison of once and twice daily application. Current Medical Research and Opinion4, 214
11.
McKenzieAWStoughtonRB (1962) Methods for comparing percutaneous absorption of steroids. Archives of Dermatology86, 608
12.
McKenzieAW (1966) Comparison of steroids by vasoconstriction. British Journal of Dermatology78, 182
13.
OrtegaE (1975) Adrenal suppression by clobctasol propionate. The Lancet1, 1,200
14.
PallagrosiAU (1975) Betamethasone dipropionate (Diprosone): A new topical steroid. A multinational, multicentre evaluation. Journal of International Medical Research3 (4), 275
15.
SparkesCGWilsonL (1974) The clinical evaluation of a new topical corticosteroid, clobctasol propionate. Brtish Journal of Dermatology90, 197
16.
StaughtonRCDAugustPJ (1975) Cushings Syndrome and pituitary-adrenal suppression due to clobetasol propionate. British Medical Journal2, 419
17.
TanRSH (1974) Pustular psoriasis with adrenal suppression following topical corticosteroids. Proceedings of the Royal Society of Medicine67, 719
18.
VigliogliaPA (1972) Local application of betamethasone dipropionate in the treatment of psoriasis. La Semana Médica140, 325
19.
WalkerS R (1974) The effect of plasma corticosteroid levels on the short-term topical application of clobetasol propionate. British Journal of Dermatology91, 339
20.
WoodbridgeP (1974) The use of a new topical steroid in General Practice. Practitioner212, 732
21.
WortzelMH (1975) A new corticosteroid for moderate/severe dermatoses. Clinical Medicine82, 23