This paper reports on the use of a single daily dose of dothiepin hydrochloride (Prothiaden). The results from a metabolism study using [14C] dothiepin were used to calculate the daily variations in blood levels after once daily and thrice daily dose regimes. A clinical study on the use of a single daily dose of 75 mg of dothiepin showed this type of regime to be well tolerated and efficacious in the treatment of 105 depressed patients in general practice. Compared to a thrice daily regime the once daily dose appeared to be more beneficial on symptomatic insomnia during the early treatment period.
Get full access to this article
View all access options for this article.
References
1.
MarchantB (1974) Internal Report, The Boots Company Ltd
2.
PearceJ BReesW Linford (1974) A double-blind comparison of three times daily and single night dose of the tricyclic antidepressant dothiepin. Journal of International Medical Research2, 12
3.
ReesJ AMarshB D (1975) The outcome of dothiepin treatment in 1900 depressed patients. International Pharmacopsychiatry10, 54
4.
RockliffB W (1971) A brief rating scale for antidepressant drug trials. Comprehensive Psychiatry12, 122
