Changes in the electro-encephalogram, and in the electro-oculogram electromyogram, ECG, blood supply, blood pressure, electrical skin activity and neurological/psychiatric findings, were investigated in 100 patients given single administrations of 200 mg of pentoxifylline (BL 191). It is concluded from the changes in the EEG wave patterns that pentoxifylline produces a beneficial effect on the cerebral processes contributing to bio-electrical brain activity. Pentoxifylline can be classed as a substance with microcirculatory/metabolic effects on the brain, which lead to stimulation of psychomotor behaviour.
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References
1.
BlanquetP (1972) Produit K 119 S (BL 191)—Radiocirculographies isotopiques cerebrales chez l'homme. Unpublished report
2.
BoksayIGanserV (1974) Effect of Pentoxifylline on Cerebral Oedema in Cats. Neurology24, 487
3.
van der DriftJ HA (1974) Fünfundzwanzig Jahre Elektroencephalographie bei zerebrovaskulären Krankheiten. Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie115, 155
4.
EhrlyA M (1975) Improvement of the Flow Properties of Blood; a new therapeutic approach in occlusive arterial disease. XXI Annual Meeting of the American College of Angiology, Puerto Rico February 1975
5.
GastparH (1974) The inhibition of Cancer Cell Stickiness by the Methylxanthine Derivative Pentoxifylline (BL 191). Thrombosis Research5, 277
6.
GottsteinU (1974) Zur Pathogenese zerebraler Durchblutungsstörungen. Therapiewoche24, 3083
7.
HayashiSOzawaH (1974) Cyclic 3,5-Nucleotide Phosphodiesterase (PDE) and the Inhibitory Effect of BL 191 on PDE in Rat, Brain and Heart. Chemical and Pharmaceutical Bulletin23, 587
8.
HeidrichHOttM (1974) Vasodilatantien und Blutviskosität. Herz/Kreisl6, 542
9.
HoneggerH (1973) Untersuchung der zentralen Durchblutung mit Hilfe der Ophthalmodynamographie. Folia Angiologia21, 207
10.
JovanovićU J (1972) Polygraphische Registrierungen nach parenteraler Applikation von 3,7-Dimethyl-1-(5-oxohexyl)-xanthin (BL 191). Arzneimittel Forschung22, 994
11.
JovanovićU JDürriglVRoginaV (1971) Studies on the bio-electrical activity of the brain and results of psychological tests following the ingestion of Tacitin and alcohol. International Symposium on Relaxation Therapy for Psychosomatic Disorder, St Moritz, January 1971
12.
JovanovićU JBrockerEDürriglVHajusekFKirstDRoginaVRouikJStojanovicVTan-EliB (1972) Vigilanz und Schlaf bei Gesunden und Depressiven unter Wirkung von Maprotilin. In: Depressive Zustände, Editor KielholzPStuttgartHuber, p 180
13.
SeyfeddinpurNStefanovichVBoksayIGlatzelJ (1973) Der Einfluss von Pentoxifyllin auf das c3,5-AMP im Liquor beim psychoorganischen Syndrom. 3rd Jugoslavian Psychopharmacology Meeting, May 1973
14.
StefanovichV (1974) Concerning Specificity of the Influence of Pentoxifylline on various cyclic AMP Phosphodiesterases. Research Communications in Chemical Pathology and Pharmacology8, 673
