The antidiarrhoeal effect of difenoxin hydrochloride versus diphenoxylate was studied in a single-blind trial. The results obtained with these substances in the treatment of diarrhoea are described, and the effect of difenoxin hydrochloride on patients with chronic liver diseases is dealt with.
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References
1.
BarowskyHSchwartzSA (1962) Method for evaluating diphenoxylate hydrochloride. Comparison of its antidiarrheal effect with that of camphorated tincture of opium. Journal of the American Medical Association (JAMA), 180, 1058
2.
Basic Medical Information, difenoxin hydrochloride (1972) Cilag-Chemie Ltd, Schaffhausen/Switzerland
3.
BondBBrinckenhoffWOFishmanJHawkerPGIsonLJMcMichaelLASilverSAStollLJWilliamsDTA (1966) Treatment of diarrhoea with a synthetic compound. The Practitioner197, 815
4.
CayerDSohmerF (1961) Long-term clinical studies with a new constipating drug, diphenoxylate hydrochloride. North Carolina Medical Journal22, 600
5.
Council on Drugs (1964) Journal of the American Medical Association (JAMA)187, 52
6.
KasichAM (1961) Treatment of diarrhoea in irritable colon, including preliminary observation with a new antidiarrheal agent, diphenoxylate hydrochloride (Lomotil). American Journal of Gastroenterology35, 46
7.
LichensteinJ (1965) A Clinical Study of diphenoxylate in the treatment of diarrhoea. Current Therapeutic Research7, 176
8.
MerloMBrownCH (1960) The effect of diphenoxylate hydrochloride and diarrhoea. American Journal of Gastroenterology34, 625
9.
NiemeggersCJELenaertsFMJanssenPA (1972) Difenoxin (R 15 403), the active metabolite of diphenoxylate (R 1132). Difenoxin, a potent, orally active and safe antidiarrheal agent in rats. Arzneimittel-Forschung22, 516
10.
Van DesstappenGVantrapenGVanderbrouckeT (1960) Long-term clinical studies with R 1132, a new constipating drug. Gastroenterology39, 725
11.
Van NuetenJM (1968) The effect of diphenoxylate on the peristaltic reflex of the guinea pig ileum. Archives Internationales de Pharmalodynamie. et de Therapie171, 243
