Abstract
Xipamid has been found to exert an effective anti-hypertensive effect in combination with methyldopa (four patients), propranolol (five patients), methyldopa and propranolol (one patient) and bethanidine (one patient), also bethanidine and propranolol (two patients).
A double-blind study was performed in ten patients and xipamid 40 mg and 20 mg produced a significant fall in blood pressure, but the difference in effect between the two dosages was insignificant.
Xipamid produced a fall in serum potassium below the normal range in half the patients.
Xipamid is an effective anti-hypertensive drug that exerts an additive effect with other anti-hypertensive drugs in common with many other diuretic agents.
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