Treatment of Amoebic Rectocolitis: Comparison of the Efficacy of Tinidazole and Metronidazole with High Dosage over a Short Term

Abstract

The therapeutic efficacy of tinidazole administered over a two-day period was assessed in a group of patients with amoebic rectocolitis and compared to the activity of metronidazole administered to a test group, with the same condition, over the same period of time at equivalent dosage. Twenty patients participated in the study and were randomly assigned to two groups of ten. The therapeutic efficacy of both drugs was similar at equivalent doses, however tinidazole was quicker in healing the distal and proximal colonic lesions caused by the vegetative forms of the parasite.