A double-blind controlled comparative clinical trial of Org GB 94 and imipramine was conducted in general practice. Fifty-five patients were treated with Org GB 94 (60 mg daily) and fifty-four with imipramine (150 mg daily). In the doses employed both agents were equally effective in relieving depression over a four week treatment period. Tolerance of the two agents was similar. Although no statistically significant differences emerged, with regard to both therapeutic effect and some side-effects a trend in favour of Org GB 94 was apparent.
Get full access to this article
View all access options for this article.
References
1.
Burg van derWJBontaILDelobelleJ (1970) A novel type of substituted piperazine with high antiseretonin potency. Journal of Medicinal Chemistry13, 35
2.
CassanoGBCastrogiovanniPContiL (1974) Clinical experiences with GB 94. A new tetracyclic antidepressant compound. Journal of Pharmacol5, (2), 17
3.
CochranWG (1954) Biometrics10, 443, 447
4.
FellPJQuantockDCvan der BurgWJ (1973) The human pharmacology of GB 94—a new psychotropic agent. European Journal of Clinical Pharmacology5, 166
5.
FleischhauerJAl-ShaltiBBråndltA (1973) Bericht über eine erste klinische Prüfung von Mianserin (GB 94) einem tetrazylkischcn Antidepressivum, im offenen Versuch. Arzneimittel Forschung23, 1808
6.
ItilT MPolvanNHsuW (1972) Clinical and EEG effects of GB 94, a ‘tetracyclic’ antidepressant (EEG model in discovery of a new psychotropic drug). Current Therapeutic Research14, 395
7.
KafoeWFLeonardBE (1973) The effect of a new tetracyclic antidepressant compound. Org GB 94, on the turnover of dopamine, noradrenaline and serotonin in the rat brain. Archives of International Pharmacodynamic206, 389
8.
LeonardBE (1974) Some effects of a new tricyclic antidepressant compound, Org GB 94, on the metabolism of monoamines in the rat brain. Psychopharmacologia36, 221
9.
LeonardBEKafoeWF (1974) Comparison of effects of Org GB 94 with some tricyclic antidepressants on brain monoamine metabolism in the rat. Journal of Pharmacology5, (2), 59
10.
Report from the Biometrie LaboratoryGeorge Washington University, Washington, D.C.
11.
van RiezenH (1972) Different central effects of the 5-HT antagonists mianserin and cyproheptadine. Archives of International Pharmacodynamics198, 256
12.
VargaftigBBCoignetJLde VosCJ (1971) Mianserin hydrochloride: peripheral and central effects in relation to antagonism against 5-hydroxytryptamine and tryptaminc. European Journal of Pharmacology16, 336
13.
VogelHPBenteDHeimchenH (1974) Mianserin vs. amitriptyline—a double-blind study evaluated by the AMP-system. Journal of Pharmacology5, (2), 103
