Urinary Hormone Excretion Patterns during Low-Dose Progestogen Administration

Abstract

The effects on pituitary-ovarian function of long-term administration of 0·5 mg of lynestrenol and 0·35 mg of norethisterone in continuous daily doses were investigated in 9 female subjects. The parameters employed were the basal body temperature charts and urinary assays of LH, total oestrogen and pregnanediol.

At the start of administration, ovulation was usually inhibited, but as a rule this effect disappeared as administration continued. Corpus luteum function appeared to be reduced.