A trial was undertaken to convert patients who were habitual users of barbiturates or Mandrax to flurazepam. This was accomplished in 45 of the 57 patients (78·9°) within a period of 2 to 5 weeks. Three typical case histories are given. The flurazepam was well tolerated and apart from the metallic taste reported by four patients, no other side-effects were reported.
Get full access to this article
View all access options for this article.
References
1.
BreckenridgeAOrmeM (1971) Interaction of Benzodiazepines with Oral Anti-coagulantAnnals of the New York Academy of Science179, 421
2.
CameronJM (1971) Advances in Toxicology. Practitioner207, 543
3.
DavisonW (1971) Therapeutic Topics: No 2. A Good Night's Sleep. Modern Geriatrics1, 142
4.
GlattMM (1969) The Changing British Drug Scene (correspondence)Lancet2, 429
5.
KalesAAllenCScharfMBKalesJD (1970) Hypnotic Drugs and their Effectiveness. Archives of General Psychiatry23, 226
6.
MatthewHProudfootATAltkenRCBRaeburnJAWrightN (1969) Nitrazepam—A Safe Hypnotic. British Medical Journal3, 23
7.
RobinsonDSAmidonEL (1973) Interaction of Benzodiazepines with Warfarin in Man. The Benzodiazepines, Raven Press, New York, p 641
8.
SetterJGMaherJHSchreinerGE (1966) Barbiturate Intoxication. Archives of Internal Medicine117, 224
9.
WellsFO (1973) Prescribing Barbiturates: Drug Substitution in General Practice. Journal of the Royal College of Practitioners23 (128), 164
