Abstract
Sixty male patients aged between sixteen and thirty years suffering from acute gonococcal urethritis in whom a urethral exudate had been present from one to thirty-nine days participated in this study here described. Each patient was given one single oral dose of ampicillin-probenicid and follow-up examinations were carried out before the end of the fifth day, between the eighth and twelfth days, and in many cases also between the fifteenth and twentieth days post-dose.
In fifty-eight of the sixty cases urethral exudate disappeared and cultures were negative within ten to forty-eight hours after dosing; thus demonstrating a 96·7% cure rate.
This form of single oral dose treatment for gonorrhoea, apart from proving extremely effective, was highly acceptable to all of the patients admitted to this study and produced no side-effects.
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