Prednisolone 17-valerate, 21-acetate (Acepreval), a new non-fluorinated topical corticosteroid, was clinically tried in 146 dermatological patients. Double-blind paired comparison studies, performed in subjects presenting bilateral, symmetrical dermatoses, showed that 0·3% Acepreval was significantly (p < 0·05) more effective than 1% hydrocortisone and as effective as 0·1% betamethasone 17-valerate. In open studies, performed in patients suffering from skin diseases of various kind, Acepreval gave good to excellent responses in 88% of the cases.
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