A double-blind, paired-lesion comparison of fluocinonide 0·05% in a fatty alcohol propylene glycol base and betamethasone-17-valerate 0·1% cream in the treatment of patients with eczema or psoriasis, is described. The fluocinonide preparation, ‘Metosyn’, was significantly superior to betamethasone-17-valerate in the treatment of patients with eczema. Both topical steroids were equally effective in the treatment of psoriasis. The advantage of fluocinonide over betamethasone-17-valerate was seen mainly in those patients who had been treated with betamethasone-17-valerate preparations before the start of the investigation. Tolerance was equally good with both preparations.
McCarthyTM (1969) Release of Betamethasone Derivatives from Ointments—‘In Vivo’ and ‘In Vitro’ Studies. British Journal of Dermatology (Suppl 4) 81, 103
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ChristieGAMoore-RobinsonM (1970) Vehicle Assessment-Methodology and Results. British Journal of Dermatology (Suppl 6) 82, 93
7.
ColdmanMFLockerbieLLawsEA (1971) The Evaluation of a Novel Corticosteroid Formulation, Fluocinonide in ‘FAPG’ Base in the Blanching Test. British Journal of Dermatology85, 573
8.
KalkoffKW (1972) The Activity of Fluocinonide on Diseased and Healthy Skin in Comparison with other Topical Corticosteroids. Acta Dermatovener (Suppl 67) 52, 51
9.
McKenzieAWStoughtonRB (1962) Method for Comparing Percutaneous Absorption of Steroids. Archives of Dermatology86, 608
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NichollsJT (1972) A Multi-Centre Trial of ‘Metosyn’, a New Topical Steroid in a Complex Two-Phase Base. Current Therapeutic Research14, 259
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PortnoyBSarkanyI (1972) ‘Metosyn’ in Psoriasis and Eczema. British Journal of Dermatology86, 310
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PoulsenBJYoungECoquillaVKatzM (1968) Effect of Topical Vehicle Composition on the ‘In Vitro’ Release of Fluocinolone Acetonide and its Acetate Ester. Journal of Pharmaceutical Sciences57, 928
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RosenbergEW (1971) Fluocinonide—Preliminary Evaluation of a New Topically Applied Corticosteroid. Archives of Dermatology104, 632
14.
SarkanyIHadgraftJWBakerB (Unpublished Data)
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SarkanyIHadgraftJWCaronGABarrettCW (1965) The Role of Vehicles in the Percutaneous Absorption of Corticosteroids—An Experimental and Clinical Study. British Journal of Dermatology77, 569
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SmartJV (1963) The Sign Test. Elements of Medical Statistics103
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StoughtonRB (1969) Vasoconstrictor Activity and Percutaneous Absorption of Glucocorticosteroids—A Direct Comparison. Archives of Dermatology99, 753
