Dexamethasone (Oradexon-Organon) was used in the treatment of forty-six patients with head injuries and sixty-four patients with brain tumours. Assessments were made based on clinical judgement, direct observations of the brain during surgery and repeated angiography. The results were compared with similar cases from previous years prior to the introduction of dexamethasone. A great improvement was seen with this corticosteroid therapy when combined with the appropriate resuscitation and intensive care techniques.
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References
1.
BlindermanEEGrafCJFitzpatrickT (1962) Basic Studies in Cerebral Edema. Its control by a Corticosteroid (Solu-Medrol). Journal of Neurosurgery19, 319–324
2.
FrenchLAGalicichJH (1964) The Use of Steroids for Control of Cerebral Edema. Clinical Neurosurgery10, 212–223
3.
GalicichJHFrenchLA (1961) Use of Dexamethasone in the Treatment of Cerebral Edema Resulting from Brain Tumours and Brain Surgery. American Practitioner and Digest of Treatment12, 169–174
4.
HammargrenLLGeiseAWFrenchLA (1965) Protection against Cerebral Damage from Intracarotid Injection of Hypaque in Animals. Journal of Neurosurgery23, 418–424
5.
JacksonFE (1966) The Pathophysiology of Head Injuries. Clinical Symposia 18, no. 3. Ciba Pharmaceutical Company. Summit, New Jersey
6.
LippertRGSvienHJGrindlayJHGoldsteinNPGastineauCF (1960) The Effect of Cortisone on Experimental Cerebral Edema. Journal of Neurosurgery17, 583–589
7.
LongDMHartmanJFFrenchLA (1966) The Response of Experimental Cerebral Edema to Glucosteroid Administration. Journal of Neurosurgery24, 843–854
8.
MaxwellRELongDMFrenchLA (1971) The Effects of Glucosteroids on Experimental Cold-induced Brain Edema. Gross Morphological Alterations and Vascular Permeability Changes. Journal of Neurosurgery34, 477–487
9.
NeematallahFSaidKTalebM (1969) Contribution à la Réanimation des Traumatismes Crăniens. Annales de L'Anesthésiologie Française10, 515–527
10.
RasmussenTGulatiD R (1962) Cortisone in the Treatment of Postoperative Cerebral Edema. Journal of Neurosurgery19, 535–544
11.
RovitRLHaganR (1968) The Effects of Glucocorticoids on Abnormal Capillary Permeability following Cerebral Injury in Cats. Journal of Neuropathology and Experimental Neurology27, 277–299
12.
RowbothamGF (1964) Acute Injuries of the Head. 4th edition. E and S Livingstone, Edinburgh and London
13.
TaylorJMLevyWAMcCoyGScheinbergL (1964) Prevention of Cerebral Oedema Induced by Triethyltin in Rabbits by Cortico-steroids. Nature204, 891–892
