Thirty-three in-patients, diagnosed as suffering from schizophrenia with acute symptomatology, were involved in a double-blind cross-over trial comparing Leponex (clozapine) with placebo. Leponex was found to be effective, particularly in the control of paranoid manifestations and excited and aggressive behaviour, with rapid onset of action. The drug should however be used with some caution at this stage because of its hypotensive effects, which led to collapse in 13% of cases in the initial stages of treatment. This side-effect could be avoided by starting on low dosage.
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