A correlation was found between clinical depression and the presence of either osteoporosis or osteoarthritis. Sex, age and race influenced which disease pattern was expressed. Other research has indicated a relationship between parathyroid disease and depression. The effectiveness of lithium therapy in affective disorders is also of possible relevance.
The nature of the relationship between mineral metabolism and affective disease may well lead to an explanation of the pathogenesis of affective disorders.
Get full access to this article
View all access options for this article.
References
1.
AlbrightF (1940) Transactions of the Association of American Physicians55, 298.
2.
CattK J (1970) Hormonal control of Calcium homeostasis. The Lancet8, 255–257.
3.
CoppenA (1967) The biochemistry of affective disorders. British Journal of Psychiatry113, 1237–1264.
4.
CoppenAShawD M (1963) Mineral metabolism in melancholia. British Journal of Psychiatry2, 1439–1444.
5.
FaragallaFFlachF F (1970) Studies in mineral metabolism in mental depression. Journal of Nervous and Mental Diseases151, 120–129.
6.
FlachF F (1964) Calcium metabolism in state of depression. British Journal of Psychiatry110, 588–593.
7.
FlachF FFaragallaF (1970) The effects of imipramine and ECT on excretion of various minerals in depressed patients. British Journal of Psychiatry116, 437–438.
8.
FourmanP (1967) Effect of calcium on mental symptoms in partial parathyroid insufficiencies. The Lancet2, 914–915.
9.
HennemannP (1970) Osteoporosis. Medical World News6, 29–36.
10.
PetersenP (1968) Psychiatric disorders in primary hyperparathyresosis. Journal of Clinical Endocrinology28, 1491–1496.
11.
WachmanABernsteinD S (1968) Diet and osteoporosis. The Lancet5, 958–959.
12.
Calcium in Psychiatry (Editorial) (1968) British Medical Journal4, 5.
13.
VargaECsabaGHolloIKorefO (1968) Androgen deficit and osteoporosis in depressed female patients. Activitas Nervosa Superior10, 12–14.
