This trial was performed on 24 healthy volunteers in order to study the possible interactions between aspirin and ticlopidine.
The results confirm the inhibitory activity of aspirin on collagen-induced aggregation and that of ticlopidine on ADP-induced aggregation.
If aspirin does not modify the inhibitory effect of ticlopidine on ADP-induced aggregation, ticlopidine on the other hand potentiates the effect of aspirin on collagen-induced aggregation.
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References
1.
AbikoYAshidaSTomikawaMOgawaHKakihataKPanakE (1976) Ticlopidine, a new inhibitor of platelet aggregation and its anti-thrombotic effect. In: Abstracts Free Communications and Scientific Exhibitions, 16th Inter national Congress of Hematology n° 7-39, pp 280.
2.
BornG V R KyotoCrossM J (1963) The aggregation of blood platelets. Journal of Physiology (London)168, 1–78.
3.
BounameauxY (1970) Exploration fonctionnelle des plaquettes. Description d'un test original. In: 7th International Congress Clinical Chemistry 1969, pp 374, Karger, Basel.
4.
DacieJ VLewisS M (1975) Practical Haematology5th edition, pp 381, Churchill Livingstone, Edinburgh, London and New York.
5.
HartertH (1952) Das Thrombelastogramm. Verhandlungen der Deutschen Gesellschaft fur innere Medizin58, 562.
6.
LecrubierCConardJSamamaMBousserM G (1977) Essai randomise d'un nouvel agent antiagrégant: la ticlopidine. Thérapie32, 189.
7.
MaffrandJ PEloyF (1974) Synthèse de thiénopyridines et de furopyridines d'intérêt thérapeutique. European Journal of Medicinal Chemistry9, 483.
8.
O'BrienJ R (1968) Effects of salicylates on human platelets. Lancet1, 779.
9.
StuartR K (1970) Platelet function in human beings receiving 300 mg of aspirin per day. Journal of Laboratory and Clinical Medicine75, 463.
10.
ThebaultJ JBlatrixC EBlanchardJ FPanakE A (1975) Effects of ticlopidine. a new platelet aggregation inhibitor in man. Clinical Pharmacology and Thera peutics18, 485.
