Roentgen Contrast Media and Fibrinolysis

Abstract

A review of the literature on the influence of contrast media (CM) on fibrinolysis showed that information currently available is contradictory, inconclusive and fragmentary. Results of some in vivo studies suggest that both ionic and nonionic CM increase fibrinolytic activity, either by lowering plasma plasminogen activator inhibitor 1 levels, by releasing endogeneous tissue plasminogen activator and/or by altering the fibrin meshwork of thrombi. Most in vitro studies on the subject contain results that are contradictory to those from in vivo studies. The discrepancies are due to obvious differences between systems which are, at best, only comparable under conditions of stagnant flow. Thus, great care should be exercised when extrapolating or interchanging data obtained in vivo and in vitro.