Correlation between Chondroitin Sulfate Iron Colloid-Enhanced MR Imaging and the Histological Grade of Hepatocellular Carcinoma

Abstract

The association between contrast enhancement by chondroitin sulfate iron colloid (CSIC) and the histological grade of hepatocellular carcinoma (HCC) was evaluated in 24 patients diagnosed by histological examination of surgical specimens (26 nodules: 11 well-differentiated and 15 poorly—moderately-differentiated nodules). In the well-differentiated HCC nodules, the tumor—liver contrast to noise ratio (CNR) was not significantly increased after i.v. CSIC injection on both T1-weighted and T2-weighted images. In the moderately-poorly-differentiated HCC, CNR was significantly increased after CSIC administration on both T1-weighted and T2-weighted images (p<0.01). MR imaging using CSIC may be useful for diagnosing the degree of HCC differentiation.

Keywords

Liver neoplasms MR imaging —contrast medium

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References

Kamba

Suto

Kato

: Initial experiences of chondroitin sulfate iron colloid-enhanced MR imaging in patients with hepatocellular carcinoma. Comparative study with CT during arterial portography. Int. Hepatol. Commun. 1 (1993), 200.

Kato

Suto

Matsuo

: Chondroitin sulfate iron colloid as an MR contrast agent for the hepatic reticuloendothelial system. J. Comput. Assist. Tomogr. 17 (1993), 603.

Okuhata

: An experimental study on MR lymphography with various iron colloid agents. (In Japanese.). Nippon Acta Radiol. 52 (1992), 1148.

Nakanishi

Kurata

Yoshimura

Oise

: Chondroitin sulfate iron colloid for intravenous injection (1st report). Physico-chemical property and pharmacological significance. (In Japanese). Yakugaku Zasshi 86 (1966), 46.

Sugihara

Nakashima

Kiyomatsu

Edamitsu

Kojiro

: Pathomorphologic study on macrophages in hepatocellular carcinoma. (In Japanese). Acta Hepatol. Jpn. 31 (1990), 12.

Suto

Kato

Matsuo

: Chondroitin sulfate iron colloid as MR contrast agent in differentiation between hepatocellular carcinoma and adenomatous hyperplasia. Acta Radiol. 34 (1993), 226.