A double-blind randomized, clinical trial was conducted in 9 hospitals comparing the use of non-ionic contrast media (CM) iopromide 300 (Ultravist) and iohexol 300 (Omnipaque) during peripheral arteriography in a total of 446 patients. After premedication with morphine-scopolamine each patient was given two consecutive injections of 50 ml CM at a rate of 12 ml/s above the aortic bifurcation. Both CM were well tolerated. There were no differences between the two substances as far as general tolerance, pulse rate, blood pressure, sensation of heat or pain after CM injection were concerned.
AlménT.: Contrast agent design. Some aspects of the synthesis of water-soluble contrast agents of low osmolality. J. Theor. Biol.24 (1969), 216.
2.
AlménT.BoijsenE.LindellS. E.: Metrizamide in angiography. I. Femoral angiography. Acta Radiol. Diagnosis18 (1977), 33.
3.
AspelinP.: Effect of ionic and non-ionic contrast media on red cell deformability in vitro. Acta Radiol. Diagnosis20 (1979), 1.
4.
CramerB. M.SchlegelE.: Relationship between pain in arteriography and the osmolality of the contrast medium. In:Contrast media from the past to the future, p. 53. Edited by FelixR.Georg Thieme Verlag, Stuttgart1987.
5.
GraingerR. G.: Osmolality of intravascular radiological contrast media. Br. J. Radiol.53 (1980), 739.
6.
GraingerR. G.: Formulation and clinical introduction of low osmolality contrast media. Radiologe21 (1981), 261.
7.
FletcherE. W. L.: A comparison of iopamidol and iohexol in peripheral angiography. Br. J. Radiol.57 (1984), 1043.
8.
KatayannnaH.YamaguchiK.KozukaT.TakashimaT.SeezP.MatsuuraK.: Adverse reactions to ionic and non-ionic contrast media. A report from the Japanese committee on the safety of contrast media. Radiology175 (1990), 621.
9.
KeysserR.: Survey of the clinical trial programme with Ultravist. In:Contrast media from the past to the future, p. 41. Edited by FelixR.Georg Thieme Verlag, Stuttgart1987.
10.
ManciniG. B. J.BlomquistJ. N.BhargavaV.: Hemodynamic and electrocardigraphic effects in man of a new non-ionic contrast agent (Iohexol). Advantages over standard ionic agents. Am. J. Cardiol.51 (1983), 1218.
11.
NymanU.AlménT.: Effects of contrast media on aortic endothelium. Experiments in the rat with non-ionic and ionic monomeric and monoacidic dimeric contrast media. Acta Radiol. (1980) Suppl. No. 362, p. 65.
12.
NymanU.AlménT.LandtmanM.: Effect of contrast media on femoral blood flow. Comparison between non-ionic and ionic monomeric and monoacidic dimeric contrast media in the dog. Acta Radiol. (1980) Suppl. No. 362, p. 43.
13.
NymanU.NilssonP.WestergrenA.: Pain and hemodynamic effects in aortofemoral angiography. Clinical comparison of iohexol, ioxaglate and metrizamide. Acta Radiol. Diagnosis23 (1982), 389.
SteinerR. M.GraingerR. G.MenonN.WeissD.KanofskyP. B.MendukeH.: The effect of contrast media of low osmolality on the peripheral arterial blood flow in the dog. Clin. Radiol.31 (1980), 621.
16.
VlahosL.DimakakosP.MoulopoulouA.: Comparative study between iohexol and iopromide for aortofemoral arteriography. Radiologe27 (1987), 581.
17.
WaldronR. L.RyanR. N.: Effects of contrast agents on the blood-brain barrier. Radiology116 (1975), 195.
18.
WilmsG.BaertA. L.KeysserR.RouxE.: Double blind cross-over study of Ultravist 300 and Omnipaque 300 in bifemoral arteriography. In:Contrast media from the past to the future, p. 97. Edited by FelixR.Georg Thieme Verlag, Stuttgart1987.
