Abstract
The changes in plasma concentrations of atrial natriuretic peptide were investigated in 10 patients who were examined for peripheral vessel disease by aorto-femoral angiography. All patients received 6×40 ml contrast medium (iohexol, 300 mg I/ml) plus an initial test dose of 15 ml, resulting in a total mean dose of 255 ml injected into the abdominal aorta. The contrast medium injections produced a significant increase in plasma atrial natriuretic peptide concentration (p<0.02). Furthermore a significant decrease was seen in systolic blood pressure (p<0.04). It is concluded that the plasma concentration of atrial natriuretic peptide increases after intraarterial injection of contrast medium, and that atrial natriuretic peptide might play a role in the hemodynamic changes seen after intravascular injections of contrast medium.
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