Clinical Comparison of 99 Tc m -Hmpao Labelled Leucocytes and 99 Tc m -Nanocolloid in the Detection of Inflammation

Abstract

Forty-five patients with various inflammatory diseases were imaged with ⁹⁹Tc^m-HMPAO labelled leucocytes and ⁹⁹Tc^m-nanocolloid within 7 days. The overall sensitivity of ⁹⁹Tc^m-leucocytes was 97% and that of ⁹⁹Tc^m-nanocolloid 59% and both agents had a 100% specificity. The ⁹⁹Tc^m-leucocyte method showed reliable results in various inflammatory and infectious conditions, and seems suitable as a primary imaging method. On the contrary, ⁹⁹Tc^m-nanocolloid cannot be recommended for use in inflammatory bowel diseases, soft tissue abscesses or prosthetic vascular graft infections. However, ⁹⁹Tc^m-nanocolloid gave reliable information in inflammatory and infectious bone and joint diseases in which it had a 90% sensitivity and 100% specificity. In those lesions the ⁹⁹Tc^m-nanocolloid method may be useful, because it is simple, fast and cheap. Yet, further evaluation is needed.

Keywords

Radionuclide imaging,comparative studies inflammation,radionuclide studies

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