A double-blind, cross-over trial of the non-ionic, low-osmolar contrast medium iohexol (Omnipaque) and the ionic, low-osmolar medium ioxaglate (Hexabrix) at concentrations of 300 mg I/ml was carried out in 107 consecutive patients with arterial insufficiency of the lower limbs. The purpose of the study was to observe possible ‘carry-over’ effects from any of the contrast media, and to evaluate patient discomfort such as pain, adverse reactions, or effect on peripheral blood pressure. No carry-over effect was seen. Ioxaglate caused less injection pain and heat sensations than iohexol, and showed less effect on the systemic blood pressure.
DahlströmK.ShawD. D.ClaussW. et coll.: Summary of U.S. and European intravascular experience with iohexol based on the clinical trial program. Invest. Radiol.20 (1985) Suppl., S117.
2.
HagenB.: Iohexol and iopromide. Two new non-ionic water-soluble radiographic contrast media. Randomized, inter-individual double-blind study versus ioxaglate in peripheral angiography. In: Contrast media in urography, angiography and computerized tomography, p. 78. Edited by TaenzerV.ZeitlerE., Georg Thieme Verlag, Stuttgart1983.
3.
HolderJ. C.DalrympleG. V.: Pain and aortofemoral arteriography. Importance of chemical structure and osmolality of contrast agents. Invest. Radiol.16 (1981), 508.
4.
LangeS.: Die lokale Schmerzreaktion bei der Extremitäten-angiographie und ihre Abhängigkeit von der Kontrastmittelkonzentration. Röntgen-Blätter34 (1981), 231.
5.
MevesM.KieferH.: Klinische Erfahrungen mit Ioxaglat, einem neuen Kontrastmittel für Angiographie. Fortschr. Röntgenstr.133 (1980), 657.
6.
MontgomeryD. C.: Design and analysis of experiments. Second edition. Wiley, New York1984.
7.
SacksB. A.EllisonH. P.BartekS. et coll.: A comparison of Hexabrix and Renografin 60 in peripheral angiography. Amer. J. Roentgenol.140 (1983), 975.
8.
SpeckU.SiefertH. M.KlinkG.: Contrast media and pain in peripheral arteriography. Invest. Radiol.15 (1980) Suppl. No. 6, S335.
9.
ValkJ.CrezéeF.SlegteR. G. M. Olislagers-De: Comparison of iohexol 300 mg I/ml and Hexabrix 320 mg I/ml in central angiography. Neuroradiology26 (1984), 217.
10.
ZachrissonB. F.JohanssonR.BjörkL.: Two new contrast media in peripheral arteriography. A double blind study in patients with arterial insufficiency in the legs. Fortschr. Röntgenstr. 132 (1980), 208.
