The renal handling of dimercaptosuccinic acid and hippuran differs. This might be used in unilateral obstructive nephropathy in order to predict potential functional recovery following intervention. The theory was evaluated on a retrospective basis in 17 patients, who primarily had a nephrostomy. If the DMSA-uptake rate in the diseased kidney was more than 10 per cent higher than that of hippuran, the uptake rate of hippuran increased following relief of obstruction. Use of the two radiopharmaceuticals, thus, may have great impact on the clinical decision, since in case of a difference some function may be saved by immediate intervention.
BinghamJ. B.MaiseyM. N.: An evaluation of the use of 99Tcm-dimercaptosuccinic acid (DMSA) as a static renal imaging agent. Brit. J. Radiol.51 (1978), 599.
2.
ChipperP. J.ChisholmG. D.HargreaveT. B.MerrickM. V.: “Technetium DMSA and the prediction of recovery in obstructive uropathy. Brit. J. Urol.53 (1981), 492.
3.
ChisholmG. D.ChipperP. J.WallaceD. M. A.HargreaveT. B.MerrickM. V.: DMSA scan and the prediction of recovery in obstructive uropathy. Europ. Urol.8 (1982), 227.
4.
CoganM. G.: Tubulo-interstitial nephropathies. A pathophysiologic approach. West. J. Med.132 (1980), 134.
5.
De MaeyerP.SimonsM.OosterlinckW.De SyW. A.: A clinical study of 99mTechnetium dimercaptosuccinic acid uptake in obstructed kidneys. Comparison with creatinine clearance. J. Urol.128 (1982), 8.
6.
EvanA. P.TannerG. A.BlomgrenP.KnoppL. C.: Proximal tubule morphology after single nephron obstruction in the rat kidney. Kidney Int.30 (1986), 818.
7.
JensenH.MogensenP.MunckO.GieseJ.: A new technique of renography with electronically assisted kidney localization. Brit. J. Radiol.50 (1977), 908.
8.
MunckO.SvendsenU. G.NielsenS. L.MogensenP.GammelgardJ.: Individuel nyrefunktion bestemt med 99mTechnetium-dimercaptoravsyre og 131I-hippuran. (In Danish.)Ugeskr. Læger143 (1981), 3219.
9.
ProvoostA. P.Van AkenM.: Renal handling of technetium-99m DMSA in rats with proximal tubular dysfunction. J. Nucl. Med.26 (1985), 1063.
10.
TaylorA.JrLalloneR.: Differential renal function in unilateral renal injury. Possible effects of radiopharmaceutical choice. J. Nucl. Med.26 (1985), 77.
11.
TestaH. J.: Radiopharmaceuticals. In: Nuclear medicine in urology and nephrology, p. 233. Edited by O'ReillyP. H.ShieldsR. A.TestaH. J., Butterworths, London1986.
12.
Van LuijkW. H. J.PiersD. A.BeekhuisH.MeijerS.: Renal handling of technetium-99m DMSA. Further evidence of glomerular filtration and proximal tubular reabsorption. J. Nucl. Med.27 (1986), 1943.
13.
WrightF. S.HowardsS. S.: Obstructive injury. In: The kidney. Second edition, p. 2008. Edited by BrennerB. M.RectorF.B.Jr. W. B. Saunders Co., Philadelphia1981.
14.
YeeC. A.LeeH. B.BlaufoxM. D.: 99mTc-DMSA renal uptake. Influence of biochemical and physiological factors. J. Nucl. Med.22 (1981), 1054.
