Magnetic Resonance Imaging in Primary Amyloidosis

Abstract

Twelve patients with primary amyloidosis (AL) were investigated with magnetic resonance imaging (MRI). In 9 patients an abnormal thickening of the heart walls was present and in 2 macroglossia was found at MRI. T1 was significantly increased in liver (p<0.05) and subcutaneous fat (p<0.01) while it was decreased in the spleen (p<0.05). T2 was significantly decreased (p<0.01) in the spleen in patients with amyloidosis, while it was not significantly altered in the liver or subcutaneous fat. After therapy T1 of the liver was reduced towards normal values in 4 patients. It is concluded that MRI might be a method to quantitate the amount of amyloid deposits in the tissue, and that the effect of therapy may be monitored with this technique.

Keywords

Amyloidosis MR studies therapy monitoring

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References

Benditt

E. P.

Eriksen

: Amyloid protein SAA is associated with high density lipoprotein from human serum. Proc. Natl. Acad. Sci. (USA) 74 (1977), 4025.

Calkins

Cohen

A. S.

: Diagnosis of amyloidosis. Bull. Rheum. Dis. 10 (1960), 215.

Costa

P. P.

Fibueria

A. S.

Bravo

F. R.

: Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy. Proc. Natl. Acad. Sci. (USA) 75 (1978), 4499.

Ericsson

Hemmingsson

Jung

: Proton relaxation in a multicompartmental system with exchange, simulating human tissue. Acta Radiol. Diagnosis 26 (1985), 745.

Glenner

G. G.

: Amyloid deposits and amyloidosis. The beta-fibrilloses. New Engl. J. Med. 302 (1980), 1283, 1333.

Glenner

G. G.

Terry

Harada

Isersky

Page

: Amyloid fibril proteins. Proof of homology with immunoglobulin light chains by sequence analysis. Science 172 (1971), 1150.

Kyle

R. A.

Greipp

P. R.

: Amyloidosis (AL). Clinical and laboratory features in 229 cases. Mayo Clin. Proc. 58 (1983), 665.

Kyle

R. A.

Greipp

P. R.

Garton

J. P.

Gertz

M. A.

: Primary systemic amyloidosis. Comparison of Melphalan/Prednisone versus Colchicine. Amer. J. Med. 79 (1985), 708.

Nyman

Ericsson

Hemmingsson

Jung

Sperber

Thuomas

K.Å.

: T1, T2 and relative proton density at 0.35 T for spleen, liver, adipose tissue and vertebral body. Accepted for publication in J. Nucl. Magn. Res. Med.

10.

Sletten

Westermark

Natvig

J. B.

: Senile cardiac amyloid is related to prealbumin. Scand. J. Immunol. 12 (1980), 503.

11.

Westermark

Benson

Olofsson

B. O.

: Fine needle aspiration biopsy of abdominal subcutaneous fat tissue for the diagnosis and typing of amyloidosis. In: Amyloidosis, p. 613. Edited by Glenner

Osseman

E. F.

Benditt

E. P.

Calkins

Cohen

A. S.

Franklin

D. Zucker

. Plenum Press, New York 1986.

12.

Westermark

Benson

Olofsson

B. O.

Stenkvist

: A new method for the diagnosis of systemic amyloidos. Arch. Intern. Med. 132 (1973), 522.