The central and renal haemodynamic effects after intravenous infusion (1 ml/s) of a non-ionic (iohexol) and an ionic (metrizoate) contrast medium were investigated in 16 pigs. The injected contrast media induced marked haemodynamic changes compared with normal saline. However, there were no significant differences between the ionic and the non-ionic media. It was concluded that the effects were only partially caused by an increase in the blood volume due to the injected volume. In addition, the effects related to the viscosity, the osmolality and other not specified pharmacodynamic properties of the media are proposed to be of importance.
Get full access to this article
View all access options for this article.
References
1.
AakhusT.SommerfeltChr.StormorkenH.DahlströmK.: Tolerance and excretion of iohexol after intravenous injection in healthy volunteers. Preliminary report. Acta radiol. (1980) Suppl. No. 362, p. 131.
2.
AlménT.AspelinP.: Cardiovascular effects of ionic monomeric and ionic dimeric and non-ionic contrast media. Effects in animals on myocardial contractile force, pulmonary and aortic blood pressure and aortic endothelium. Invest. Radiol.10 (1975), 519.
3.
AlménT.AspelinP.LevinB.: Effect of ionic and non-ionic contrast media on aortic and pulmonary arterial pressure. An angiographic study in rabbits. Invest. Radiol.10 (1975), 519.
4.
AlménT.AspelinP.NilssonP.: Aortic and pulmonary arterial pressure after injection of contrast media into the right atrium of the rabbit. Comparison between metrizoate, iozaglate and iohexol. Acta radiol. (1980) Suppl. No. 362, p. 37.
5.
AspelinP.: Effect of ionic contrast media on morphology of human erythrocytes. Acta radiol. Diagnosis19 (1978), 675.
6.
EldridgeF.HultgrenH.LinC.BlumenfeldM.: A study of clinical reactions to venous angiocardiography. New Engl. J. Med.252 (1955), 259.
7.
ForrestJ.HowardsS.GillenwaterJ.: Osmotic effect of intravenous contrast agents on renal function. J. Urol.125 (1981), 147.
8.
GanzW.SwanH. J. C.: Measurement of blood flow by thermodilution. Amer. J. Cardiol.29 (1972), 241.
9.
GanzW.TamuraK.MarcusH. S.RonosoR.YoshidaS.SwanH. J. C.: Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation44 (1971), 181.
10.
HabereyM.SchröderG.MannesmannG.: Cardiovascular effects of iohexol in the rat and the isolated rabbit heart. Acta radiol. (1980) Suppl. No. 362, p. 29.
11.
HäggmarkS.BiberB.SiödinJ.-G.WinsöO.GustavssonB.ReizS.: The continuous thermodilution method for measuring high blood flows. Scand J. clin. Lab. Invest.42 (1982), 315.
12.
HigginsC. B.GerberK. H.MattreyR. F.SlutskyR. A.: Evaluation of the hemodynamic effects of intravenous administration of ionic and non-ionic contrast materials. Radiology142 (1982), 681.
13.
HilalS.: Hemodynamic changes associated with the intra-arterial injection of contrast media. Radiology86 (1966), 615.
14.
LindgrenE. (Editor): Iohexol. A non-ionic contrast medium. Pharmacology and toxicology. Acta radiol. (1980) Suppl. No. 362, p. 9.
15.
ReadR.: Cause of death in angiocardiography. J. Thorac. Cardiovasc. Surg.38 (1959), 685.
16.
VockP.FuchsW. A.: Conventional versus low osmolality non-ionic and dimeric intravenous contrast media. Noninvasive evaluation of hemodynamic effects. In:Contrast media in radiology, p. 285. Edited by AmielM.. Springer Verlag, Berlin, Heidelberg1981.
