The ionic contrast medium diatrizoate used in high-dose unilateral nephroangiography in dogs produced an abnormal nephrogram, ‘patchy contrast medium retention’, and a marked decrease in renal blood flow in five of eight injected kidneys. Increased glomerular permeability (albuminuria), reduced glomerular filtration rate (creatinine clearance), and reduced osmotic diuresis were demonstrated in all selectively injected kidneys.
Get full access to this article
View all access options for this article.
References
1.
BerdonW. E.SchwartzR. H.BeckerJ.BakerD. H.: Tamm-Horsfall proteinuria. Its relationship to prolonged nephrogram in infants and children and to renal failure following intravenous urography in adults with multiple myeloma. Radiology92 (1969), 714.
2.
ByrdL.ShermanR. L.: Radiocontrast-induced acute renal failure. A clinical and pathophysiologic review. Medicine58 (1979), 270.
3.
CaldicottW. J. H.HollenbergN. K.AbramsH. L.: Characteristics of response of renal vascular bed to contrast media. Evidence for vasoconstriction induced by renin-angiotensin system. Invest. Radiol.5 (1970), 539.
4.
ForrestJ.HowardsS.GillenwaterJ.: Osmotic effects of intravenous contrast agents on renal function. J. Urol.125 (1981), 147.
5.
GolmanK.HoltåsS.: Proteinuria produced by urographic contrast media. Invest. Radiol. (1980) Suppl. No. 15, p. S61.
6.
HarkonenS.KjellstrandC.: Contrast nephropathy. Amer. J. Nephrol.1 (1981), 69.
7.
HelanderC.-G.: Nephrographic effect and renal arteriographic damage. An experimental study. Acta radiol. (1958) Suppl. No. 163, pp. 30, 38, 81.
8.
HoltåsS.TejlerL.: Proteinuria following nephroangiography. IV. Comparison in dogs between ionic and non-ionic contrast media. Acta radiol. Diagnosis20 (1979), 13.
9.
HoltåsS.AlménT.TejlerL.: Proteinuria following nephroangiography. II. Influence of contrast medium and catheterization in dogs. Acta radiol. Diagnosis19 (1978), 33.
10.
AlménT.Proteinuria following nephroangiography. III. Role of osmolality and concentration of contrast medium in renal arteries in dogs. Acta radiol. Diagnosis19 (1978), 401.
11.
AlménT.HellstenS.TejlerL.: Proteinuria following nephroangiography. VI. Comparison between metrizoate and metrizamide in man. Acta radiol. Diagnosis21 (1980), 491.
12.
KatzbergR. W.MorrisT. W.BurgenerF. A.KammD. E.FischerH. W.: Renal renin and hemodynamic responses to selective renal artery catheterization and angiography. Invest. Radiol.12 (1977), 381.
13.
KatzbergR. W.MorrisT. W.BurgenerF. A.KammD. E.FischerH. W.SchulmanG.MeggsL. G.CaldicottW. J. H.DamianoM. M.HollenbergN. K.: Mechanism of the renal response to contrast medium in dogs. Decrease in renal function due to hypertonicity. Invest. Radiol.18 (1983), 74.
14.
KråkenesJ.ElsayedS.GöthlinJ.FarstadM.: Proteinuria after selective nephroangiography in man. Comparison of three contrast media. Acta radiol. Diagnosis21 (1980), 401.
MulladayT.WakimK.HuntJ.KincaidO.: Effects of diatrizoate sodium on kidney function in dogs. J. Amer. med. Ass.184 (1963), 716.
20.
ObrezI.AbramsH.: Temporary occlusion of the renal artery. Effects and significance. Radiology104 (1972), 545.
21.
ReedJ. R.WilliamsR. H.LukeR. G.: The renal hemodynamic response to diatrizoate in normal and diabetic rats. Invest. Radiol.18 (1983), 536.
22.
RheaW. G.KillenD.FosterJ.: Renal recovery following contrast medium injury. Surgery57 (1965), 53.
23.
RusselS. B.SherwoodT.: Monomer/dimer contrast media in the renal circulation. Experimental angiography. Brit. J. Radiol.47 (1974), 268.
24.
SherwoodT.LavenderJ. P.: Does renal blood flow rise or fall in response to diatrizoate?Invest. Radiol.4 (1969), 327.
25.
SherwoodT.LavenderJ. P.GreenspanR.H.: Renal magnification angiograms in the dog. Observations on responses to vasodilators and surgical trauma. Brit. J. Radiol.42 (1969), 241.
26.
SmithH. W.: The kidney. Structure and function in health and disease. 4th printing (1964), p. 233. Oxford University Press, Inc.New York1951.
27.
TejlerL.AlménT.HoltåsS.: Proteinuria following nephroangiography. I. Clinical experiences. Acta radiol. Diagnosis18 (1977), 634.
