Diagnostic value of color Doppler ultrasound combined with blood inflammatory markers in threatened abortion and pregnancy outcomes in early pregnancy

Abstract

Background

Threatened abortion is a general complication during pregnancy.

Purpose

To analyze the predictive effect of color Doppler ultrasound (CDUS) combined with blood inflammatory markers in threatened abortion and pregnancy outcomes in early pregnancy.

Material and Methods

Uterine artery blood flow parameters, blood inflammatory marker levels, influencing factors of threatened abortion and pregnancy outcomes, and predictive value of CDUS combined with blood inflammation markers for threatened abortion and pregnancy outcomes were analyzed.

Results

The abortion group exhibited higher resistance index (RI), pulsation index (PI), and systolic peak flow velocity/end-diastolic flow velocity (S/D), and serum IL-1β, neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) than the continued pregnancy and control groups, and a higher proportion of subchorionic hematomas than the continued pregnancy group; IL-1β, NLR, PI, and SD were risk factors for threatened abortion. The area under the curve (AUC) of IL-1β, NLR, MLR, RI, PI, and S/D for combined prediction of threatened abortion was higher than that for individual predictors. Previous abortion history, IL-1β, NLR, PI, and S/D were risk factors for adverse pregnancy outcomes in threatened abortion. The AUC of IL-1β, NLR, RI, PI, and S/D for combined prediction of pregnancy outcomes in threatened abortion was higher than for individual predictors.

Conclusion

CDUS of uterine artery blood flow parameters combined with blood inflammatory markers has high predictive value for threatened abortion and pregnancy outcomes.