Myocardium microcirculation study in a healthy Chinese population using 3.0-T cardiac magnetic resonance intravoxel incoherent motion imaging

Abstract

Background

Intravoxel incoherent motion imaging (IVIM) can non-invasively evaluate diffusion and microvascular perfusion.

Purpose

To explore the myocardium microcirculation of a healthy Chinese population by using cardiac magnetic resonance (CMR) IVIM.

Material and Methods

A total of 80 healthy volunteers (44 men, 36 women) who underwent 3.0-T CMR examination were enrolled. All participants had cardiac cine imaging and short-axis CMR-IVIM of the left ventricle (LV) using multiple b-values. The consistency of the IVIM parameters was assessed by intraclass correlation coefficient (ICC) and the Bland–Altman test. Spearman correlation analysis was performed between IVIM parameters and age, and body mass index (BMI). The differences of IVIM parameters were analyzed between gender and different ages.

Results

LV end-diastolic volume (EDV), end-systolic volume (ESV), LVmass, cardiac output (CO), and BMI in the male group were higher than those in the female group (P<0.05). IVIM parameters had good intra-observer and inter-observer consistency (≥0.75). Bland–Altman analysis also showed good intra-observer and inter-observer consistency. ADC_fast decreased with increasing female age (rs = –0.37; P = 0.01), while IVIM parameters had no correlation with BMI regardless of sex. ADC_fast in the female group had a statistical difference between different age groups. The ADC_slow and f in the male group were lower than those in the female group (P<0.05); however, there was no statistical difference in ADC_fast between genders.

Conclusion

IVIM parameters in healthy Chinese volunteers provided good consistency. There was a negative correlation between ADC_fast and age in the female group.