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Abstract

Background

Few studies have examined the feasibility and efficiency of performing ultrasound and contrast-enhanced ultrasound (CEUS) after percutaneous laser ablation (PLA) of cervical metastatic lymph nodes from thyroid cancer.

Purpose

To investigate and describe the use of conventional ultrasound and CEUS in evaluating PLA of metastatic lymph nodes.

Material and Methods

PLA was performed in a small, prospective, observational study of 21 metastatic lymph nodes in 17 thyroid cancer patients who underwent radical thyroid resection. CEUS was conducted prior to PLA and 1 h and seven days after ablation. Conventional ultrasound examination of all nodes was performed during follow-up after ablation. We observed contrast agent perfusion in the lymph nodes, calculated perfusion defect volumes using CEUS and determined the rates of reduction for metastatic lymph nodes for a mean duration of 17.86 ± 4.704 months (range = 12–27 months).

Results

CEUS demonstrated that the perfusion defect volume was larger on day 7 than on day 1 post-ablation in 47% of the ablated nodes. Compared to the largest diameters and volumes pre-PLA, the corresponding post-PLA values significantly decreased (P < 0.05 versus baseline). No statistically significant change in thyroglobulin (Tg) levels before and after PLA was observed in this study (P > 0.05 versus baseline).

Conclusion

CEUS can be effectively used to distinguish the margins of ablated regions, assess the accuracy of PLA, and monitor short-term changes in necrotic areas. However, long-term follow-up assessments of the curative effect of PLA will predominantly rely on conventional ultrasonography.

Keywords

Percutaneous laser ultrasound intravenous contrast agents lymphatic metastases

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References

Fontenot

Deniwar

Bhatia

et al.

Percutaneous ethanol injection vs reoperation for locally recurrent papillary thyroid cancer: a systematic review and pooled analysis. JAMA Otolaryngol Head Neck Surg 2015; 141: 512–518.

Vannucchi

Covelli

Perrino

et al.

Ultrasound-guided percutaneous ethanol injection in papillary thyroid cancer metastatic lymph-nodes. Endocrine 2014; 47: 648–651.

Papini

Bizzarri

Bianchini

et al.

Percutaneous ultrasound-guided laser ablation is effective for treating selected nodal metastases in papillary thyroid cancer. J Clin Endocrinol Metab 2013; 98: E92–E97.

Mauri

Cova

Ierace

et al.

Treatment of Metastatic lymph nodes in the neck from papillary thyroid carcinoma with percutaneous laser ablation. Cardiovasc Intervent Radiol 2016; 39: 1023–1030.

Yue

Chen

Wang

et al.

Locoregional control of recurrent papillary thyroid carcinoma by ultrasound-guided percutaneous microwave ablation: a prospective study. Int J Hyperthermia 2015; 31: 403–408.

Yue

Wang

et al.

Ultrasound-guided percutaneous microwave ablation of solitary T1N0M0 papillary thyroid microcarcinoma: initial experience. Int J Hyperthermia 2014; 30: 150–157.

Rong

Wang

et al.

Percutaneous radiofrequency ablation with contrast-enhanced ultrasonography for solitary and sporadic renal cell carcinoma in patients with autosomal dominant polycystic kidney disease. World J Surg Oncol 2016; 14: 193–193.

Zhai

et al.

Radiofrequency ablation for hepatocellular carcinoma: utility of conventional ultrasound and contrast-enhanced ultrasound in guiding and assessing early therapeutic response and short-term follow-up results. Ultrasound Med Biol 2015; 41: 2400–2411.

Chen

Yang

et al.

Role of contrast enhanced ultrasound in radiofrequency ablation of metastatic liver carcinoma. Chin J Cancer Res 2012; 24: 44–51.

10.

Wang

et al.

Ultrasonography-guided percutaneous radiofrequency ablation for cervical lymph node metastasis from thyroid carcinoma. J Cancer Res Ther 2014; 10(Suppl.): C144–C149.

11.

Zhang

Gong

et al.

Application of high-resolution ultrasound, real-time elastography, and contrast-enhanced ultrasound in differentiating solid thyroid nodules. Medicine (Baltimore) 2016; 95: e5329–e5329.

12.

de Stefano

Scognamiglio

Di Martino

et al.

The role of CEUS in characterization of superficial lymph nodes: a single center prospective study. Oncotarget 2016; 7: 52416–52422.

13.

d’Herbomez

Lion

Beron

et al.

[Advances in thyroglobulin assays and their impact on the management of differentiated thyroid cancers]. Ann Biol Clin (Paris) 2016; 74: 21–27.

14.

Evans

Tennant

Perros

. Serum thyroglobulin in the monitoring of differentiated thyroid cancer. Scand J Clin Lab Invest Suppl 2016; 245: S119–S123.

15.

Hasbek

Turgut

Kilicli

et al.

Importance of postoperative stimulated thyroglobulin level at the time of 131I ablation therapy for differentiated thyroid cancer. Asian Pac J Cancer Prev 2014; 15: 2523–2527.

16.

Vural

Akkas

Ercakmak

et al.

Prognostic significance of FDG PET/CT on the follow-up of patients of differentiated thyroid carcinoma with negative 131I whole-body scan and elevated thyroglobulin levels: correlation with clinical and histopathologic characteristics and long-term follow-up data. Clin Nucl Med 2012; 37: 953–959.

17.

Zhou

. Detection of the single-session complete ablation rate by contrast-enhanced ultrasound during ultrasound-guided laser ablation for benign thyroid nodules: a prospective study. Biomed Res Int 2016; 2016: 9565364–9565364.

18.

Zhou

Jiang

Zhan

et al.

Ultrasound-guided percutaneous laser ablation of unifocal T1N0M0 papillary thyroid microcarcinoma: preliminary results. Eur Radiol 2017; 27: 2934–2940.

19.

Yao

et al.

Contrast-enhanced ultrasonography follow-up after radiofrequency ablation in normal rabbit kidney. Arch Med Sci 2013; 9: 608–613.

20.

Mauri

Porazzi

Cova

et al.

Intraprocedural contrast-enhanced ultrasound (CEUS) in liver percutaneous radiofrequency ablation: clinical impact and health technology assessment. Insights Imaging 2014; 5: 209–216.

21.

Gao

Zheng

Cui

et al.

Predictive value of quantitative contrast-enhanced ultrasound in hepatocellular carcinoma recurrence after ablation. World J Gastroenterol 2015; 21: 10418–10426.

22.

Liang

et al.

Role of contrast-enhanced ultrasound in evaluating the efficiency of ultrasound guided percutaneous microwave ablation in patients with renal cell carcinoma. Radiol Oncol 2013; 47: 398–404.

23.

Sumagin

Prizant

Lomakina

et al.

LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. J Immunol 2010; 185: 7057–7066.

24.

Zhou

Keane

Reed

et al.

Thromboembolic complications of cardiac radiofrequency catheter ablation: a review of the reported incidence, pathogenesis and current research directions. J Cardiovasc Electrophysiol 1999; 10: 611–620.

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Role of ultrasound in the assessment of percutaneous laser ablation of cervical metastatic lymph nodes from thyroid carcinoma

Abstract

Background

Purpose

Material and Methods

Results

Conclusion

Keywords

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References

Supplementary Material