Comparison of mammography,ultrasound,and MRI in size assessment of ductal carcinoma in situ with histopathologic correlation

Abstract

Background

The ability to accurately assess tumor size in ductal carcinoma in situ (DCIS) is an important clinical issue when selecting the appropriate treatment plan.

Purpose

To compare the accuracy of using mammography, ultrasound (US), and magnetic resonance imaging (MRI) to assess DCIS tumor size based on imaging and histopathological findings.

Material and Methods

Fifty-six patients with DCIS were included. Mammography, US, and MRI were reviewed, and the accuracy of the measured tumor sizes were compared with the imaging and histopathological parameters.

Results

If visible, tumor measurements demonstrated high reliability with the pathologically determined size, with the best results obtained using US (k = 0.851) followed by mammography (k = 0.815) and MRI (k = 0.738). Tumor size assessment was significantly more accurate when the lesion was shown as a mass on US (P = 0.003) or MRI (P < 0.001) with minimal and mild background parenchymal enhancement (P = 0.016) on MRI. When mammography was used to assess tumor size, the tumors with positive estrogen receptor status and luminal A subtype demonstrated a significantly more accurate tumor size.

Conclusion

The combination of US and MRI, in addition to mammography, has an important role in assessing the exact tumor extent of DCIS.