Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique enabling visualization and measurement of white matter tracts. Attention deficit hyperactivity disorder (ADHD) has been studied with DTI earlier with variable results, yet there is little research on remitted ADHD.
Purpose
To compare the brain white matter between ADHD drug naïve subjects whose ADHD symptoms have mostly subsided and healthy controls.
Material and Methods
Tract-based spatial statistics (TBSS) was used to compare 30 subjects with adolescent ADHD with control subjects at the age of 22–23 years. The study population was derived from a population-based Northern Finland Birth Cohort 1986. Fractional anisotropy (FA), mean diffusivity (MD), and measures of diffusion direction (λ1–3) were calculated. Permutation testing was used to test for differences in mean values of FA, MD, and λ1–3 between the groups. The results were corrected for multiple comparisons across the whole white matter skeleton.
Results
The ADHD group showed increased FA related to decreased radial diffusivity in the left forceps minor (P < 0.05). In the vicinity along the same tract, axial diffusion was significantly decreased without any significant effect on FA. No between-group difference in MD was observed. Regressor analysis revealed no gender-, IQ- or GAF-related changes. After removal of left handed subjects the statistical significance was only barely lost.
Conclusion
In a setting with remitted ADHD, the results may represent a compensatory mechanism in the left forceps minor.
American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV), American Psychiatric Press: Washington, DC, 1994.
2.
American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders, 5th edition (DSM-5), American Psychiatric Press: Washington, DC, 2013.
3.
FaraoneSVBiedermanJMickE. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med2006; 36: 159–165.
4.
BasserPJ. Inferring microstructural features and the physiological state of tissues from diffusion weighted images. NMR Biomed1995; 8: 333–344.
CaoQSunLGongG. The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: a combined morphometric and diffusion tensor MRI study. Brain Res2010; 1310: 172–180.
7.
PavuluriMNYangSKamineniK. Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit/hyperactivity disorder. Biol Psychiatry2009; 65: 586–593.
8.
KobelMBechtelNSpechtK. Structural and functional imaging approaches in attention deficit/hyperactivity disorder: does the temporal lobe play a key role?Psychiatry Res2010; 183: 230–236.
9.
DavenportNDKaratekinCWhiteT. Differential fractional anisotropy abnormalities in adolescents with ADHD or schizophrenia. Psychiatry Res2010; 181: 193–198.
10.
QiuMGYeZLiQY. Changes of brain structure and function in ADHD children. Brain Topogr2011; 24: 243–252.
11.
NagelBJBathulaDHertingM. Altered white matter microstructure in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry2011; 50: 283–292.
12.
ChuangTCWuMTHuangSP. Diffusion tensor imaging study of white matter fiber tracts in adolescent attention-deficit / hyperactivity disorder. Psychiatry Res2013; 211: 186–187.
LiQSunJGuoL. Increased fractional anisotropy in white matter of the right frontal region in children with attention-deficit/hyperactivity disorder: a diffusion tensor imaging study. Neuro Endocrinol Lett2010; 31: 747–753.
15.
SilkTJVanceARinehartN. White-matter abnormalities in attention deficit hyperactivity disorder: a diffusion tensor imaging study. Hum Brain Mapp2009; 30: 2757–2765.
16.
TammLBarnea-GoralyNReissAL. Diffusion tensor imaging reveals white matter abnormalities in attention-deficit/hyperactivity disorder. Psychiatry Res2012; 202: 150–154.
17.
DramsdahlMWesterhausenRHaavikJ. Adults with attention-deficit/hyperactivity disorder - a diffusion-tensor imaging study of the corpus callosum. Psychiatry Res2012; 201: 168–173.
18.
KonradADielentheisTFEl MasriD. Disturbed structural connectivity is related to inattention and impulsivity in adult attention deficit hyperactivity disorder. Eur J Neurosci2010; 31: 912–919.
19.
KonradADielentheisTFMasriDE. White matter abnormalities and their impact on attentional performance in adult attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci2012; 262: 351–360.
20.
CorteseSImperatiDZhouJ. White matter alterations at 33-year follow-up in adults with childhood attention-deficit / hyperactivity disorder. Biol Psychiatry2013; 74: 591–598.
21.
MakrisNBukaSLBiedermanJ. Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connections. Cereb Cortex2008; 18: 1210–1220.
22.
van EwijkHHeslenfeldDJZwiersMP. Diffusion tensor imaging in attention deficit/hyperactivity disorder: A systematic review and meta-analysis. Neurosci Biobehav Rev2012; 36: 1093–1106.
SmalleySLMcGoughJJMoilanenIK. Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish population. J Am Acad Child Adolesc Psychiatry2007; 46: 1575–1583.
25.
KaufmanJBirmaherBBrentD. Schedule for affective disorders and schizophrenia for scholl-age children – present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry1997; 36: 980–988.
26.
FirstMBSpitzerRLGibbonM. Structured clinical interview for DSM-IV axis I disorders, clinical version (SCID-CV), American Psychiatric Press: Washington, DC, 1996.
27.
Wechsler D. Wechsler adult intelligence scale - third edition. Manual. San Antonio, TX: The Psychological Corporation, 1997.
28.
EndicottJSpitzerRLFleissJL. The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry1976; 33: 766–771.
BodeMKMattilaMLKiviniemiV. White matter in autism spectrum disorders – evidence of impaired fiber formation. Acta Radiol2011; 52: 1169–1174.
31.
CorteseSKellyCChabenaudC. Towards systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. Am J Psychiatry2013; 169: 1038–1055.
32.
SongSKSunSWJuWK. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage2003; 20: 1714–1722.
33.
SongSKSunSWRamsbottomMJ. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage2002; 17: 1429–1436.
34.
DijkhuizenRMvan der MarelKOtteWM. Functional MRI and diffusion tensor imaging of brain reorganization after experimental stroke. Transl Stroke Res2012; 3: 36–43.
35.
LiZBacon MooreATynerC. Asymmetric connectivity reductions and its relationship to “HAROLD” in aging brain. Brain Res2009; 1295: 149–158.
36.
ImperatiDColcombeSKellyC. Differential Development of Human Brain White Matter Tracts. PLoS One2011; 6: e23437–e23437.
37.
SilkTJVanceARinehartN. Structural development of the basal ganglia in attention deficit hyperactivity disorder: a diffusion tensor imaging study. Psychiatry Res2009; 172: 220–225.
38.
NiederhoferH. Hand preference in attention deficit hyperactivity disorder. Percept Mot Skills2005; 101: 808–810.
39.
GhanizadehA. Lack of association of handedness with inattention and hyperactivity symptoms in ADHD. J Atten Disord2013; 17: 302–307.
40.
ZhuTLiuXGaughMD. Evaluation of measurement uncertainties in human diffusion tensor imaging (DTI)-derived parameters and optimization of clinical DTI protocols with a wild bootstrap analysis. J Magn Reson Imaging2009; 29: 422–435.
