Impact of slice thickness on semi-automated measurements for volume and whole-tumor attenuation of colorectal hepatic metastases in multislice computed tomography

Abstract

Background

Volumetric and whole-tumor attenuation assessment of tumor are of value in assessment of treatment.

Purpose

To assess the impact of slice thickness on semi-automatic analyses (volume, whole-tumor attenuation) for small colorectal hepatic metastases.

Material and Methods

Computed tomography (CT) data of patients with colorectal hepatic metastases at 1.5-, 3-, and 5-mm slice thickness were semi-automatically evaluated for volume and whole-tumor attenuation by two radiologists independently. Statistical analysis included paired samples t-test and concordance correlation coefficient (CCC) analysis according to the longest axial tumor diameter (10–20 mm, 20–30 mm, 30–40 mm).

Results

A total of 62 patients (32 men and 30 women) with 62 target tumors were included. The mean volume was significantly higher at 3- and 5-mm slice thicknesses in comparison with the reference (1.5 mm) for the target tumors between 10 mm and 20 mm (P = 0.0295, CCC = 0.9394 for 3 mm; P = 0.0029, CCC = 0.5129 for 5 mm, respectively) and at 5 mm slice thickness for the target tumors between 20 mm and 30 mm (P = 0.0071, CCC = 0.9102). For whole-tumor attenuation measurements, the significant difference was only seen at 5-mm slice thicknesses in comparison with the reference (1.5 mm) for the target tumors between 10 and 20 mm (P = 0.0015, CCC = 0.9389).

Conclusion

Slice thickness of 1.5 mm might be suggested for semi-automated volumetric measurements, and slice thickness of no more than 3 mm for whole-tumor CT attenuation in hepatic metastasis between 10 mm and 20 mm.