Objective. To assess the feasibility and validity of using a discrete choice experiment format to elicit health preferences in adolescents by comparing illogical choices and choice-blindness rates between adults and adolescents; and to explore the relationship between personality traits and health-state choices. Methods. A convenience sample of adults and adolescents (12 to 17 y old) were recruited from around Chicago, USA. A personality inventory was administered, followed by pairwise comparisons of 6 health-state scenarios which asked each candidate to select their preferred choice. Health-state descriptions were based on a simplified 3-dimension version of the EQ-5D (mobility, pain, depression, each with 3 levels). For 2 scenarios, the respondent’s preferred choice was switched; if the respondent did not notice the switch they were considered “choice blind”. Logistic regression evaluated the association of personality, gender, and age with choice blindness and health-state choice. Results. Ninety-nine respondents were recruited (44% adults). Comparing adolescents to adults, there was no significant difference in the rate of illogical preferences (9% v. 12%) or in preferring dead to the worst health state (56% v. 64%) (P > 0.05). Choice-blindness rates were significantly higher in adolescents (35%) than adults (9%) (P < 0.01). The adjusted odds of choice blindness in adolescents was 6.6 (95% CI = 1.8 to 23.8; P = 0.004). Conscientiousness was significantly associated with health-state choice in 3 of the 6 models predicting health-state choice (using P < 0.1 as a threshold). Conclusions. The results of this exploratory study suggest it is feasible to conduct choice experiments in adolescents; however, adolescents are significantly more likely to demonstrate choice blindness. Psychological traits may be noteworthy predictors of health-state choices, with conscientiousness independently associated with several health-state choices.